ATP-Binding Cassette, Sub-Family G (WHITE), Member 8 (ABCG8) antibody

Antigen: ATP-Binding Cassette, Sub-Family G (WHITE), Member 8 (ABCG8)

Synonyms: GBD4, STSL, MGC142217, AI114946, sterolin-2, 1300003C16Rik, ABCG8, zgc:172358

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN268853

Additional Information

Alternative name: ABCG8

Gene ID: 64241

Immunogen: A synthetic peptide from the N-terminal region of human ABCG8 protein.

Cross-Reactivity: Human

Description: ATP-binding cassette (ABC) transporter genes are involved in the regulation of theamount of dietary cholesterol retained in the body. ABCG8, expressed at high levels inthe liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption andpromote biliary excretion of sterols. The mutated form of this transporter can lead tosterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessivedisorder, characterized by hyperabsorption of sterols and the inability to excrete sterolsinto bile. Alternate Names: anti-ATP binding cassette sub family G (WHITE) member 8 (sterolin 2) antibody,anti-ATP binding cassette sub family G member 8 antibody, anti-MGC142217 antibody,anti-Sterolin 2 antibody, anti-STSL antibody, anti-ATP binding cassette G8 antibody. Related Diseases: Atherosclerosis, Coronary Artery Disease

Specificity: Specific for ABCG8. Species Reactivity: Human. Does not appear to cross react with mouse. Localization: Integral membrane protein, multi-pass membrane protein.

Application Details

Application Notes: Suggested working dilutions: Western Blot 1:500

Concentration: 1 mg/ml

Purification: Aff - Purified

Buffer: Preservative: 0.1% sodium azide.

Storage: Store at 4C. Do not freeze.

Research Area: Cancer, Atherosclerosis, Metabolism

Restrictions: For Research Use only

Publications

Garcia, Wilund, Arca et al.: "Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein." in: Science (New York, N.Y.), Vol. 292, Issue 5520, pp. 1394-8, 2001 (PubMed).

Lu, Lee, Hazard et al.: "Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively." in: American journal of human genetics, Vol. 69, Issue 2, pp. 278-90, 2001 (PubMed).

Schmitz, Langmann, Heimerl: "Role of ABCG1 and other ABCG family members in lipid metabolism." in: Journal of lipid research, Vol. 42, Issue 10, pp. 1513-20, 2001 (PubMed).

Remaley, Bark, Walts et al.: "Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster." in: Biochemical and biophysical research communications, Vol. 295, Issue 2, pp. 276-82, 2002 (PubMed).

Kobayashi, Takanezawa, Hirata et al.: "Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1." in: Journal of lipid research, Vol. 47, Issue 8, pp. 1791-802, 2006 (PubMed).

Mathur, Watt, Field: "Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid." in: Journal of lipid research, Vol. 48, Issue 2, pp. 395-404, 2007 (PubMed).