Scavenger Receptor Class B, Member 1 (SCARB1) antibody

Details for Product No. ABIN268870
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Antigen
Synonyms CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1, AI120173, CD36, Cd36l1, Cla-1, Cla1, D5Ertd460e, Hdlq1, Hlb398, SR-B1, SRBI, Srb1, mSR-BI, cb1015, SCARB1, Scarb1
Reactivity
Mouse (Murine)
(48), (45), (41), (17), (17), (17), (4), (2)
Host
Rabbit
(56), (8), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
(48), (20), (18), (18), (13), (11), (11), (10), (9), (5), (3), (2), (1)
Pubmed 3 references available
Catalog no. ABIN268870
Quantity 25 µL
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Immunogen A peptide from the extracellular domain (residues 230-380) of ScavengerReceptor-BI/BII that was expressed as two tandem copies in bacteria using the pETsystem.
Specificity 400-134 is specific for SR-BI and SR-BII. Species Reactivity: Reacts with mouse. Previous lots have been shown to react with rat and humanScavenger Receptors BI and Scavenger Receptors BII, as well. Localization: Lysosome, lysosomal membrane, multi-pass membrane protein.
Cross-Reactivity Mouse (Murine)
Purification Serum
Alternative Name SCARB1
Background High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and theirplasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI andSR-BII (previously known as SR-BI.2) are the alternatively spliced products of a singlegene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmicdomain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDLcholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency thanSR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenictissues.Although the role of these scavenger receptors is not completely clear, SR-BII mRNAresults from the alternative splicing of SR-BI precursor transcripts with both isoformsmediating selective transfer of lipid between HDL and cells. Therefore, the relativeexpression and functional activities of these two isoforms create a potential means ofregulating selective lipid transfer between HDL and cells. Alternate Names: anti-SR-B1/B2 antibody, anti-SR-BI/BII antibody, anti-Scavenger Receptor-BI/BIIantibody, anti-Scavenger Receptor-B1/B2 antibody, anti-RED1 antibody, anti-RED 1antibody, anti-RED-1 antibody.
Gene ID 20778
Application Notes Suggested working dilutions: immunofluorescence 1/1000,Western Blot 1/1000
Restrictions For Research Use only
Format Liquid
Buffer Preservative: 0.02% sodium azide.
Preservative Sodium azide
Storage -20 °C
General Silver: "A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34042-7, 2002 (PubMed).

Kocher, Yesilaltay, Cirovic et al.: "Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism." in: The Journal of biological chemistry, Vol. 278, Issue 52, pp. 52820-5, 2003 (PubMed).

Harder, Meng, Rippstein et al.: "SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells." in: The Journal of biological chemistry, Vol. 282, Issue 2, pp. 1445-55, 2007 (PubMed).

Hosts (56), (8), (5)
Reactivities (48), (45), (41), (17), (17), (17), (4), (2)
Applications (48), (20), (18), (18), (13), (11), (11), (10), (9), (5), (3), (2), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (12), (5), (3), (3)
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