Apolipoprotein A-V (APOA5) antibody

Antigen: Apolipoprotein A-V (APOA5)

Synonyms: RAP3, Apoav, 1300007O05Rik, APOAV, APOA-V, MGC126836, MGC126838, MGC108612, APOA5, MGC140487, rap3, apoav, apoa-v

Clonality: Monoclonal (1G5G9)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Catalog no.: ABIN268873

Additional Information

Alternative name: Apolipoprotein A V (ApoA V)

Gene ID: 116519

Immunogen: Ni-NTA purified full-length recombinant human APOA5 expressed in E. Coli strain BL21(DE3).

Cross-Reactivity: Human

Isotype: IgG1

Clone: 1G5G9

Description: Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serumtriglyceride concentrations. An ApoA5 mouse knock-out model produced anapproximately four-fold increase in serum triglycerides, whereas a knock-in model withhuman ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. Inaddition, peroxisome proliferator-activated receptor-4 (PPAR-alpha) agonists, which areused clinically to lower serum triglyceride concentrations, cause increased ApoA5mRNA expression. Recently, it was demonstrated that ApoA5 is present in humanserum detected by polyclonal antibodies against both the NH2 and COOH termini,although at much lower concentrations than other apolipoproteins. Alternate Names: anti-Apo-A5 antibody, anti-ApoA5 antibody, anti-Apolipoprotein A5 antibody, anti-ApoA-V antibody, anti-Apolipoprotein A-V antibody, anti-ApoA-V antibody. Related Diseases: Coronary Artery Disease, Hypertriglyceridemia

Specificity: Species Reactivity: Reacts with human. 83% sequence identity with Bovine, 79% sequence identity withRat, 78% sequence identity with Mouse proteins.

Application Details

Application Notes: Suggested working dilutions: Western Blot 1:500-1:2,000 (ECL). Positive Controls: HEPG2 cells

Concentration: 3.6 mg/ml

Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Research Area: Metabolism

Restrictions: For Research Use only

Publications

Pennacchio, Olivier, Hubacek et al.: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).