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Apolipoprotein A-V (APOA5) antibody

Details for Product No. ABIN268873
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Antigen
Synonyms APOA5, MGC140487, rap3, apoav, apoa-v, APOAV, RAP3, apo-AV, apoA-V, 1300007O05Rik, Apoav
Reactivity
Human
(99), (14), (14), (12), (8), (1)
Host
Mouse
(59), (41), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
(78), (77), (11), (10), (9), (6), (4), (1), (1)
Pubmed 2 references available
Quantity 0.025 mL
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Catalog No. ABIN268873
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Immunogen Ni-NTA purified full-length recombinant human Apolipoprotein A5 expressed in E. Coli strain BL21 (DE3). Immunogen sequence has 83% identity to bovine, 79% identity to rat and 78% identity to mouse.
Clone 1G5G9
Isotype IgG1 kappa
Purification Ascites
Alternative Name Apolipoprotein A V (ApoA V)
Background Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serumtriglyceride concentrations. An ApoA5 mouse knock-out model produced anapproximately four-fold increase in serum triglycerides, whereas a knock-in model withhuman ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. Inaddition, peroxisome proliferator-activated receptor-4 (PPAR-alpha) agonists, which areused clinically to lower serum triglyceride concentrations, cause increased ApoA5mRNA expression. Recently, it was demonstrated that ApoA5 is present in humanserum detected by polyclonal antibodies against both the NH2 and COOH termini,although at much lower concentrations than other apolipoproteins. Alternate Names: anti-Apo-A5 antibody, anti-ApoA5 antibody, anti-Apolipoprotein A5 antibody, anti-ApoA-V antibody, anti-Apolipoprotein A-V antibody, anti-ApoA-V antibody. Related Diseases: Coronary Artery Disease, Hypertriglyceridemia
Gene Symbol: APOA5
Gene ID 116519
UniProt Q6Q788
Research Area Metabolism
Application Notes This Apolipoprotein A5 antibody is useful for ELISA, Western Blot and Immunohistochemistry paraffin embedded sections. In Western blot a band at approximately 41 kDa is seen. This antibody does not work in ICC/IF.
Recommended dilutions: ELISA 1:100-1:2000, ICC/IF (Negative), Immunohistochemistry 5 µg/mL, Immunohistochemistry-Paraffin 5 µg/mL, Western Blot 1:500-1:2000
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
General Pennacchio, Olivier, Hubacek et al.: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).

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