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LAMP2 antibody

LAMP2 Reactivity: Mouse FACS, IP, IHC (fro), IHC (p), IHC (zinc) Host: Rat Monoclonal M3-84 unconjugated
Catalog No. ABIN2688888
  • Target See all LAMP2 Antibodies
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Reactivity
    • 112
    • 72
    • 36
    • 16
    • 3
    • 3
    • 2
    • 1
    Mouse
    Host
    • 86
    • 41
    • 28
    Rat
    Clonality
    • 78
    • 76
    Monoclonal
    Conjugate
    • 57
    • 20
    • 19
    • 14
    • 11
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LAMP2 antibody is un-conjugated
    Application
    • 114
    • 55
    • 49
    • 36
    • 31
    • 29
    • 26
    • 14
    • 13
    • 13
    • 11
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))
    Brand
    BD Pharmingen™
    Characteristics
    The M3/84 monoclonal antibody specifically binds to CD107b which is also known as Mac-3, Lysosome-associated membrane protein 2 (LAMP-2/Lamp2/Lamp II), and Lysosomal membrane glycoprotein type B (LGP-B). CD107b is a single-pass type I transmembrane glycoprotein that constitutes a major integral membrane protein of lysosomes and may play a role in lysosomal function. CD107b is also expressed on the surface of mouse mononuclear phagocytes. Surface expression of the 92-110- kDa glycoprotein antigen increases during differentiation of monocytes to activated macrophages and may play a role in adhesion. The M3/84 mAb can detect CD107b antigen on tissue macrophages, thioglycollate-elicited peritoneal macrophages, and some myeloid cell lines, but not on lymphocytes or monocytes. In the bone marrow, very few cells display CD107b antigen on the surface, but a large proportion express cytoplasmic CD107b. The M3/84 antibody has also been reported to stain dendritic cells and endothelium in sections of thymus (both medulla and cortex), lymph nodes, spleen (white pulp), and gut-associated lymphoid tissue. Immunohistochemical staining of macrophages. The formalin-fixed paraffin-embedded sections of normal mouse lung were stained with M3/84 mAb (left panel) or R3-34 mAb (isotype control, right panel). Macrophages are identified by the brown labeling of their cell -surface membranes.

    BD Pharmingen™ Purified Rat Anti-Mouse CD107b - Purified - Clone M3/84 - Isotype Rat IgG1, κ - Reactivity Ms - 1 mL
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse C57Bl/6 peritoneal exudate cells
    Clone
    M3-84
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product LAMP2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    31.25 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Walker, Akporiaye, Warner, Stewart: "Characterization of subsets of bone marrow-derived macrophages by flow cytometry analysis." in: Journal of leukocyte biology, Vol. 37, Issue 2, pp. 121-36, (1985) (PubMed).

    Chen, Murphy, Willingham, Pastan, August: "Identification of two lysosomal membrane glycoproteins." in: The Journal of cell biology, Vol. 101, Issue 1, pp. 85-95, (1985) (PubMed).

    Flotte, Springer, Thorbecke: "Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets." in: The American journal of pathology, Vol. 111, Issue 1, pp. 112-24, (1983) (PubMed).

    Ralph, Ho, Litcofsky, Springer: "Expression and induction in vitro of macrophage differentiation antigens on murine cell lines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 130, Issue 1, pp. 108-14, (1983) (PubMed).

  • Target
    LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
    Alternative Name
    CD107b (LAMP2 Products)
    Synonyms
    CD107b antibody, LAMP-2 antibody, LAMPB antibody, LGP110 antibody, Lamp-2 antibody, Lamp-2a antibody, Lamp-2b antibody, Lamp-2c antibody, Mac3 antibody, cd107b antibody, lamp-2 antibody, lampb antibody, LAMP2 antibody, lamp2 antibody, DKFZp459J126 antibody, LGP-B antibody, sb:cb587 antibody, wu:fb14a06 antibody, zgc:103532 antibody, lysosomal associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 antibody, lysosomal-associated membrane protein 2 S homeolog antibody, lysosomal membrane glycoprotein 2 antibody, LAMP2 antibody, Lamp2 antibody, lamp2.S antibody, lamp2 antibody
    Background
    Synonyms: CD107b, Lamp2, LAMP-2, Lysosome-associated membrane glycoprotein 2, LGP-B
    Pathways
    Autophagy
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