IL1R2 antibody

Catalog No. ABIN2688929

Product Details anti-IL1R2 Antibody

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1R2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: CD121b, also known as interleukin-1 receptor type II (IL-1RII), has a significant role in the inflammatory response. Interleukin-1 receptor type II acts as a decoy receptor to regulate prolonged persistence of IL-1 by binding to IL-1 and preventing the formation of signaling complexes. Membrane IL-1 type II receptor forms a 60 kDa soluble IL-1 receptor type II upon proteolytic cleavage from various cell types after activation with secondary, IL-1 induced cytokines. The soluble IL-1 type II receptor consists of 398 amino acids and 29 amino acids within a short cytoplasmic domain. The MNC2 monoclonal antibody reacts with recombinant and native soluble human IL-1 receptor type II. Flow cytometric analysis for CD121b. Jurkat cells (Human T-cell leukemia, ATCC TIB-152) [Left Panel] or SR cells (Human lymphoblast, ATCC CRL-2262) [Right Panel] were stained either with a Mouse IgG1, κ isotype control (MN 555746) [dotted line] or with the Purified Mouse Anti-Human CD121b antibody (MN 552401) [solid line] in conjunction with a PE Goat Anti-Mouse Ig secondary antibody (MN 550589). Flow cytometry was performed on a BD FACSCalibur™ flow cytometry system.

BD Pharmingen™ Purified Mouse Anti-Human CD121B - Purified - Clone MNC2 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: MNC2

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-IL1R2 antibody (ABIN2688929)

Bessis, Guéry, Mantovani, Vecchi, Sims, Fradelizi, Boissier: "The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis." in: European journal of immunology, Vol. 30, Issue 3, pp. 867-75, (2000) (PubMed).

Orlando, Sironi, Bianchi, Drummond, Boraschi, Yabes, Mantovani: "Role of metalloproteases in the release of the IL-1 type II decoy receptor." in: The Journal of biological chemistry, Vol. 272, Issue 50, pp. 31764-9, (1998) (PubMed).

Target Details for IL1R2

Target: IL1R2 (Interleukin 1 Receptor, Type II (IL1R2))

Alternative Name: CD121B (IL1R2 Products)

Synonyms: CD121b antibody, CDw121b antibody, IL-1R-2 antibody, IL-1RT-2 antibody, IL-1RT2 antibody, IL1R2c antibody, IL1RB antibody, Il1r-2 antibody, IL-1R2 antibody, interleukin 1 receptor type 2 antibody, interleukin 1 receptor, type II antibody, interleukin-like antibody, IL1R2 antibody, Il1r2 antibody, KK34 antibody

Background: Synonyms: IL-1 Receptor Type II, IL-1 RII

Pathways: NF-kappaB Signaling