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TNFRSF4 antibody (Biotin)

TNFRSF4 Reactivity: Rat FACS Host: Mouse Monoclonal OX Biotin
Catalog No. ABIN2688958
  • Target See all TNFRSF4 Antibodies
    TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
    Reactivity
    • 65
    • 49
    • 31
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Rat
    Host
    • 56
    • 31
    • 13
    • 2
    Mouse
    Clonality
    • 53
    • 47
    Monoclonal
    Conjugate
    • 52
    • 12
    • 9
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TNFRSF4 antibody is conjugated to Biotin
    Application
    • 58
    • 45
    • 31
    • 15
    • 14
    • 13
    • 11
    • 10
    • 10
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Brand
    BD Pharmingen™
    Characteristics
    The OX-40 antibody reacts with the 50- kDa OX-40 Antigen (CD134), also known as OX-40 Receptor, on CD4+ T lymphocytes activated in vitro and in vivo. The antigen is a member of the NGFR/TNFR superfamily, which includes low-affinity nerve growth factor receptor, TNF receptors, the Fas antigen, CD137 (4-1BB), CD27, CD30, and CD40. CD134 supplies costimulatory signals for T-cell proliferation and effector functions. While OX-40 mAb is not mitogenic, it does augment some in vitro T-cell responses. It is also reported to block binding of OX-40 Ligand to OX-40 Antigen.

    BD Pharmingen™ Biotin Mouse Anti-Rat CD134 - Biotin - Clone OX-40 - Isotype Mouse IgG2b, κ - Reactivity Rat - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Activated rat lymph node cells
    Clone
    OX
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product TNFRSF4 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Weinberg, Vella, Croft: "OX-40: life beyond the effector T cell stage." in: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, (1999) (PubMed).

    al-Shamkhani, Birkeland, Puklavec, Brown, James, Barclay: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." in: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, (1996) (PubMed).

    Smith, Farrah, Goodwin: "The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death." in: Cell, Vol. 76, Issue 6, pp. 959-62, (1994) (PubMed).

    Mallett, Fossum, Barclay: "Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor." in: The EMBO journal, Vol. 9, Issue 4, pp. 1063-8, (1990) (PubMed).

  • Target
    TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
    Alternative Name
    CD134 (TNFRSF4 Products)
    Synonyms
    TNFRSF4 antibody, ACT35 antibody, CD134 antibody, Ly-70 antibody, Ox40 antibody, TXGP1L antibody, Txgp1 antibody, OX40 antibody, TNF receptor superfamily member 4 antibody, tumor necrosis factor receptor superfamily, member 4 antibody, TNFRSF4 antibody, Tnfrsf4 antibody
    Background
    Synonyms: OX-40 Antigen
    Pathways
    Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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