Tissue factor antibody

Catalog No. ABIN2688975

Product Details anti-Tissue factor Antibody

Target: Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tissue factor antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with a 45-47 kDa, single chain, type I transmembrane protein also known as Tissue Factor (TF). CD142 has been referred in the literature as coagulation Factor III or thromboplastin and it is expressed on activated endothelial cells and lipopolysaccharide (LPS)-stimulated monocytes/macrophages. TF associates with factor VIIa to form a complex and acts as an enzyme that initiates the blood coagulation cascade. It is known as the major initiator of clotting in normal hemostasis. CD142 can be induced by various inflammatory mediators in monocytes and vascular endothelial cells. This antibody is useful in inflammation, thrombosis and hemostasis research. Profile of LPS-stimulated peripheral blood monocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD142 - Purified - Clone HTF-1 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: HTF

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-Tissue factor antibody (ABIN2688975)

Carson, Perry, Pirruccello: "Fibroblast tissue factor: calcium and ionophore induce shape changes, release of membrane vesicles, and redistribution of tissue factor antigen in addition to increased procoagulant activity." in: Blood, Vol. 84, Issue 2, pp. 526-34, (1994) (PubMed).

McComb, Miller, Carson: "Tissue factor antigen in senile plaques of Alzheimer's disease." in: The American journal of pathology, Vol. 139, Issue 3, pp. 491-4, (1991) (PubMed).

Target Details for Tissue factor

Target: Tissue factor (F3) (Coagulation Factor III (thromboplastin, Tissue Factor) (F3))

Alternative Name: CD142 (F3 Products)

Synonyms: CD142 antibody, TF antibody, TFA antibody, PRO1557 antibody, PRO2086 antibody, TFQTL1 antibody, f3 antibody, AA409063 antibody, Cf-3 antibody, Cf3 antibody, tf antibody, zgc:112151 antibody, coagulation factor III, tissue factor antibody, transferrin antibody, coagulation factor IIIa antibody, coagulation factor III antibody, tissue factor antibody, coagulation factor IIIb antibody, coagulation factor III (thromboplastin, tissue factor) S homeolog antibody, F3 antibody, TF antibody, f3a antibody, tf antibody, f3b antibody, f3.S antibody

Pathways: Positive Regulation of Endopeptidase Activity, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling