Reacts with a 50 - 58 kDa type I glycoprotein molecule of the killer cell inhibitory receptor (KIR) family of proteins. CD158b has also been known as GLI83, p50.2, or p58.2. CD158b is composed of two extracellular Ig-like domains. It is expressed on a subset of NK cells and it may also be present on rare T cells (either CD3/TCR αβ+, or CD3/TCR γδ+). CD158b regulates NK cell mediated cytolytic activity by interacting with HLA-C alleles (Cw 1, 3, 7 and 8). This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
Kim, Chwae, Kim, Choi, Park, Kim: "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 8, pp. 3875-82, (1997) (PubMed).
Cambiaggi, Orengo, Meazza, Sforzini, Tazzari, Lauria, Raspadori, Zambello, Semenzato, Moretta, Ferrini: "The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function." in: Blood, Vol. 87, Issue 6, pp. 2369-75, (1996) (PubMed).
Colonna, Samaridis: "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." in: Science (New York, N.Y.), Vol. 268, Issue 5209, pp. 405-8, (1995) (PubMed).
Ferrini, Cambiaggi, Meazza, Sforzini, Marciano, Mingari, Moretta: "T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function." in: European journal of immunology, Vol. 24, Issue 10, pp. 2294-8, (1994) (PubMed).
Target
KIR2DL3
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))