ICOSLG antibody

Catalog No. ABIN2689136

Product Details anti-ICOSLG Antibody

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICOSLG antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with a 302 amino acid cell surface protein termed B7-H2 (B-7 homologue 2). B7-H2 binds to a CD28-like receptor inducible costimulator (ICOS) and costimulates the proliferation and cytokine production of human T cells. It is weakly expressed on peripheral blood mononuclear cells, but it is expressed on monocyte-derived dendritic cells. This antibody could be useful in the study of dendritic cell development and/or costimulatory molecules. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of B7-H2 (2D3/B7-H2) expression on CHO-B7-H2 cells analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD275 - Purified - Clone 2D3/B7-H2 - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: 2D3-B7

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-ICOSLG antibody (ABIN2689136)

Wang, Zhu, Chapoval, Dong, Tamada, Ni, Chen: "Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS." in: Blood, Vol. 96, Issue 8, pp. 2808-13, (2000) (PubMed).

Bretscher: "A two-step, two-signal model for the primary activation of precursor helper T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 1, pp. 185-90, (1999) (PubMed).

Dong, Zhu, Tamada, Chen: "B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion." in: Nature medicine, Vol. 5, Issue 12, pp. 1365-9, (1999) (PubMed).

Target Details for ICOSLG

Target: ICOSLG (Inducible T-Cell Co-Stimulator Ligand (ICOSLG))

Alternative Name: CD275 (ICOSLG Products)

Synonyms: ICOSLG antibody, AU044799 antibody, B7-H2 antibody, B7RP-1 antibody, B7h antibody, BG071784 antibody, GI50 antibody, GL50 antibody, GL50-B antibody, ICOS-L antibody, Icoslg antibody, LICOS antibody, Ly115l antibody, mKIAA0653 antibody, B7H2 antibody, B7RP1 antibody, CD275 antibody, ICOSL antibody, Icosl antibody, RGD1562791 antibody, inducible T-cell costimulator ligand antibody, icos ligand antibody, inducible T-cell co-stimulator ligand antibody, ICOSLG antibody, Icosl antibody, Icoslg antibody

Background: Synonyms: B7-H2

Pathways: Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation