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Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody (Biotin)
Alternatives Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|14 references available|
|Quantity||50 µl (1.0 mg/mL) (Variants)|
|Price||Product not available in this region.|
|Alternative name||IAP4 / BIRC5|
|Gene ID||332, 11799, 64041|
|Immunogen||Full-length recombinant human survivin.|
|Cross-Reactivity||Dog (Canine), Cat (Feline), Human, Mouse (Murine), Rat (Rattus)|
|Description||Regulated inhibition of programmed cell death (apoptosis) preserves normalhomeostasis and tissue and organ morphogenesis. Aberrations in this processcontribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have beenfound in various species, including human. IAP proteins contain one/three Cys/Hisbaculovirus IAP repeats plus a C-terminal RING finger and are thought to block anevolutionary conserved step in apoptosis.Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expressionis turned off during fetal development and is not found in non-neoplastic adult humantissues. Survivin becomes abundantly re-expressed in transformed cells and in all ofthe most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division,governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) ofadult rats following traumatic brain injury. Survivin has been found co-expressed withNeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affectregulation of neural cell proliferative responses after brain injury. Alternate Names: anti-API4 antibody, anti-Apoptosis Inhibitor 4 antibody, anti-Apoptosis inhibitor survivinantibody, anti-Baculoviral IAP repeat containing 5 antibody, anti-BIRC 5 antibody,anti-EPR 1 antibody, anti-IAP4 antibody, anti-SVV antibody, anti-TIAP antibody,anti-BIRC5 antibody.|
|Specificity||This antibody is specific for survivin. Species Reactivity: ABIN153009B recognizes human, mouse, rat, cat, and dog survivin. Other species havenot been tested. Localization: Nuclear.|
|Synonyms||API4, EPR-1, AP14, BIRC5, MGC133855, DKFZp468N162, Api4, TIAP, AAC-11, survivin40, bir5a, survivin, bir1-A, svv1, XBIR1, Xsvv1, birc5.1-A, xSurvivin, XSurvivin1, LOC398389, LOC398418, Su2, birc5.1-B, BIR1, Survivin, Survivin1, xSurvivin1, SIX, Su1, api4, svv2, birc5, epr-1, xSurvivin2|
|Application Notes||Suggested working dilutions: Western Blot 1 ug/ml,Immunohistochemistry-Paraffin 0.5 ug/ml|
|Buffer||PBS. Preservative: no preservative.|
|Storage||Store at 4C. Do not freeze.|
|Research Area||Cancer, Apoptosis/Necrosis, Neurology|
|Restrictions||For Research Use only|
Wheatley, Carvalho, Vagnarelli et al.: "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis." in: Current biology : CB, Vol. 11, Issue 11, pp. 886-90, 2001 (PubMed).
Zhu, Fukuda, Cordis et al.: "Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning." in: FEBS letters, Vol. 508, Issue 3, pp. 369-74, 2001 (PubMed).
Zeitlin, Shelby, Sullivan: "CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis." in: The Journal of cell biology, Vol. 155, Issue 7, pp. 1147-57, 2001 (PubMed).
Chakravarti, Noll, Black et al.: "Quantitatively determined survivin expression levels are of prognostic value in human gliomas." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 20, Issue 4, pp. 1063-8, 2002 (PubMed).
Fortugno, Wall, Giodini et al.: "Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function." in: Journal of cell science, Vol. 115, Issue Pt 3, pp. 575-85, 2002 (PubMed).
Giodini, Kallio, Wall et al.: "Regulation of microtubule stability and mitotic progression by survivin." in: Cancer research, Vol. 62, Issue 9, pp. 2462-7, 2002 (PubMed).
Zhang, Hazarika, Ni et al.: "Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 8, Issue 5, pp. 1234-40, 2002 (PubMed).
Yu, Leung, Ebert et al.: "Increased expression of survivin in gastric cancer patients and in first degree relatives." in: British journal of cancer, Vol. 87, Issue 1, pp. 91-7, 2002 (PubMed).
Blanc-Brude, Yu, Simosa et al.: "Inhibitor of apoptosis protein survivin regulates vascular injury." in: Nature medicine, Vol. 8, Issue 9, pp. 987-94, 2002 (PubMed).
Mahotka, Liebmann, Wenzel et al.: "Differential subcellular localization of functionally divergent survivin splice variants." in: Cell death and differentiation, Vol. 9, Issue 12, pp. 1334-42, 2002 (PubMed).
Grabowski, Kuehnel, Muehr-Wilkenshoff et al.: "Prognostic value of nuclear survivin expression in oesophageal squamous cell carcinoma." in: British journal of cancer, Vol. 88, Issue 1, pp. 115-9, 2003 (PubMed).
Miranda, Dyer, Grandis et al.: "Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 17, Issue 2, pp. 390-400, 2003 (PubMed).
Kennedy, ODriscoll, Purcell et al.: "Prognostic importance of survivin in breast cancer." in: British journal of cancer, Vol. 88, Issue 7, pp. 1077-83, 2003 (PubMed).
Hauf, Cole, LaTerra et al.: "The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint." in: The Journal of cell biology, Vol. 161, Issue 2, pp. 281-94, 2003 (PubMed).
|Hosts||Rabbit (17), Mouse (5)|
|Reactivities||Human (19), Mouse (Murine) (9), Rat (Rattus) (8), Cow (Bovine) (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1), Pig (Porcine) (1), Rabbit (1)|
|Applications||Western Blotting (WB) (20), ELISA (12), Immunohistochemistry (IHC) (9), Immunofluorescence (IF) (5), Flow Cytometry (FACS) (2), Immunoprecipitation (IP) (2)|
|Epitopes||C-Term (6), N-Term (3), AA 1-99 (1), Center (1), Transcript Variant 1 (1)|