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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody
Alternatives Immunoprecipitation (IP), Western Blotting (WB)
|14 references available|
|Quantity||25 µl (Variants)|
|Price||Product not available in this region.|
|Alternative name||IAP4 / BIRC5|
|Immunogen||Full-length recombinant human survivin.|
|Cross-Reactivity||Human, Mouse (Murine), Rat (Rattus)|
|Description||Regulated inhibition of programmed cell death (apoptosis) preserves normalhomeostasis and tissue and organ morphogenesis. Aberrations in this processcontribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have beenfound in various species, including human. IAP proteins contain one/three Cys/Hisbaculovirus IAP repeats plus a c-terminus RING finger and are thought to block anevolutionary conserved step in apoptosis.Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expressionis turned off during fetal development and is not found in non-neoplastic adult humantissues. Survivin becomes abundantly re-expressed in transformed cells and in all ofthe most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division,governing a checkpoint involved in cytokinesis while also suppressing apoptosis.Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) ofadult rats following traumatic brain injury. Survivin has been found co-expressed withNeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affectregulation of neural cell proliferative responses after brain injury. Alternate Names: anti-API4 antibody, anti-Apoptosis Inhibitor 4 antibody, anti-Apoptosis inhibitor survivinantibody, anti-Baculoviral IAP repeat containing 5 antibody, anti-BIRC 5 antibody,anti-EPR 1 antibody, anti-IAP4 antibody, anti-SVV antibody, anti-TIAP antibody,anti-BIRC5 antibody.|
|Specificity||ABIN153011 is specific for the cytoplasmic form of survivin. Species Reactivity: Human, mouse and rat survivin. Other species have not been tested. Localization: Astrocyte Marker.|
|Synonyms||API4, EPR-1, AP14, BIRC5, MGC133855, DKFZp468N162, Api4, TIAP, AAC-11, survivin40, bir5a, survivin, bir1-A, svv1, XBIR1, Xsvv1, birc5.1-A, xSurvivin, XSurvivin1, LOC398389, LOC398418, Su2, birc5.1-B, BIR1, Survivin, Survivin1, xSurvivin1, SIX, Su1, api4, svv2, birc5, epr-1, xSurvivin2|
|Application Notes||Suggested working dilutions: Western Blot 1:1000|
|Buffer||0.01M Na phosphate, 0.25M NaCl, pH7.6, 15mg/ml BSA|
|Storage||Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.|
|Research Area||Cancer, Apoptosis/Necrosis, Neurology|
|Restrictions||For Research Use only|
Ambrosini, Adida, Sirugo et al.: "Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 11177-82, 1998 (PubMed).
Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).
Li, Ackermann, Bennett et al.: "Pleiotropic cell-division defects and apoptosis induced by interference with survivin function." in: Nature cell biology, Vol. 1, Issue 8, pp. 461-6, 2000 (PubMed).
Grossman, McNiff, Li et al.: "Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma." in: The Journal of investigative dermatology, Vol. 113, Issue 6, pp. 1076-81, 2000 (PubMed).
Adida, Haioun, Gaulard et al.: "Prognostic significance of survivin expression in diffuse large B-cell lymphomas." in: Blood, Vol. 96, Issue 5, pp. 1921-5, 2000 (PubMed).
Fortugno, Wall, Giodini et al.: "Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function." in: Journal of cell science, Vol. 115, Issue Pt 3, pp. 575-85, 2002 (PubMed).
Allen, Florell, Hanks et al.: "Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression." in: Cancer research, Vol. 63, Issue 3, pp. 567-72, 2003 (PubMed).
Xu, Zhao, Ding et al.: "Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1838-44, 2004 (PubMed).
Ansell, Arendt, Grote et al.: "Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 18, Issue 3, pp. 616-23, 2004 (PubMed).
Ryan, ODonovan, Browne et al.: "Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer." in: British journal of cancer, Vol. 92, Issue 1, pp. 120-4, 2005 (PubMed).
Brocardo, Lei, Tighe et al.: "Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival." in: The Journal of biological chemistry, Vol. 283, Issue 9, pp. 5950-9, 2008 (PubMed).
Hino, Uozaki, Inoue et al.: "Survival advantage of EBV-associated gastric carcinoma: survivin up-regulation by viral latent membrane protein 2A." in: Cancer research, Vol. 68, Issue 5, pp. 1427-35, 2008 (PubMed).
Levkau, Schaefers, Wohlschlaeger et al.: "Survivin determines cardiac function by controlling total cardiomyocyte number." in: Circulation, Vol. 117, Issue 12, pp. 1583-93, 2008 (PubMed).
Huang, Fletcher, Beeharry et al.: "Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint." in: Cancer research, Vol. 68, Issue 10, pp. 3724-32, 2008 (PubMed).
|Hosts||Rabbit (17), Mouse (5)|
|Reactivities||Human (19), Mouse (Murine) (9), Rat (Rattus) (8), Cow (Bovine) (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1), Pig (Porcine) (1), Rabbit (1)|
|Applications||Western Blotting (WB) (20), ELISA (12), Immunohistochemistry (IHC) (9), Immunofluorescence (IF) (5), Flow Cytometry (FACS) (2), Immunoprecipitation (IP) (2)|
|Epitopes||C-Term (6), N-Term (3), AA 1-99 (1), Center (1), Transcript Variant 1 (1)|