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Details for Product No. ABIN268919

Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7) antibody

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Synonyms CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3, Mch3, mCASP-7, AI314680, ICE-IAP3, caspase-7, xCaspase-7, caspase7, cmh-1, ice-lap3, mch3, CASP7
»Alternatives Human
»Alternatives Mouse
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN268919
Quantity 25 µL
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Immunogen Full-length recombinant human Caspase 7 protein.
Isotype IgG1
Specificity Specific for Caspase 7. Species Reactivity: Recognizes human, rat, and mouse Caspase 7. Other species have not beentested.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Ascites
Alternative Name Caspase-7
Background Caspases are cysteine proteases, expressed as inactive precursors, that mediateapoptosis by proteolysis of specific substrates. Caspases have the ability to cleave afteraspartic acid residues. There are two classes of caspases involved in apoptosis,initiators (activation by receptor cluster) and effectors (activation by mitochondrialpermeability transition). Proapoptotic signals autocatalytically activate initiatorcaspases, such as Caspase-8 and Caspase-9. Activated initiator caspases thenprocess effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cellcollapse. Alternate Names: anti-Apoptosis related cysteine peptidase antibody, anti-Apoptosis Related CysteineProtease antibody, anti-Apoptotic Protease MCH3 antibody, anti-CASP 7 antibody,anti-CMH1 antibody, anti-ICE LAP3 antibody, anti-ICE like Apoptotic Protease 3antibody, anti-MCH3 antibody.
Gene ID 840
Research Area Apoptosis/Necrosis
Application Notes Positive Controls: HeLa and Jurkat whole cell extracts.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid. Preservative: Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Fearnhead, Rodriguez, Govek et al.: "Oncogene-dependent apoptosis is mediated by caspase-9." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 23, pp. 13664-9, 1998 (PubMed).

Kirsch, Doseff, Chau et al.: "Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c." in: The Journal of biological chemistry, Vol. 274, Issue 30, pp. 21155-61, 1999 (PubMed).

Blanc-Brude, Mesri, Wall et al.: "Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 9, Issue 7, pp. 2683-92, 2003 (PubMed).

Alternatives for antigen "Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7)", type "Antibodies"
Hosts (129), (47), (3)
Reactivities (166), (83), (71), (29), (24), (16), (12), (7), (5), (5), (4), (2), (1)
Applications (152), (53), (50), (41), (23), (20), (7), (6), (4), (4), (3), (2), (1), (1), (1)
Conjugates (7), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (21), (17), (9), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)