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Details for Product No. ABIN268920

CAF-1 Subunit antibody

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Antigen
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Application
»Alternatives Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN268920
Quantity 25 µL
Price
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Immunogen Recombinant human CAF-1p60.
Clone SS 53
Isotype IgG1
Specificity Specific for CAF-1p60. Species Reactivity: Recognizes human CAF-1p60. Other species have not been tested.
Cross-Reactivity Human
Purification Ascites
Background Chromatin assembly factor 1 (CAF-1) is a member of the histone chaperone family. It isrequired for inheritance of epigenetically determined chromosomal states, and in vitro, itpromotes the assembly of chromatin during DNA replication and DNA repair. CAF-1 isa complex of three subunits, p150, p60, and p48. This complex is localized to thenucleus of human cells.Both the composition and the biochemical activity of CAF-1 are conserved amonghuman, yeast, and Drosophila. Alternate Names: anti-p60 CAF1 antibody.
Gene ID 8208
Application Notes Western analysis: Use a 1:1,000 dilution (ECL)on crude nuclear extracts. A band isseen at 60 kDa representing CAF-1p60. In addition, this antibody may be used forimmunoprecipitation (100-500 ng of IgG).
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.1% sodium azide
Preservative Sodium azide
Storage -20 °C
Smith, Stillman: "Immunological characterization of chromatin assembly factor I, a human cell factor required for chromatin assembly during DNA replication in vitro." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 12041-7, 1991 (PubMed).

Shibahara, Stillman: "Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin." in: Cell, Vol. 96, Issue 4, pp. 575-85, 1999 (PubMed).

Green, Almouzni: "Local action of the chromatin assembly factor CAF-1 at sites of nucleotide excision repair in vivo." in: The EMBO journal, Vol. 22, Issue 19, pp. 5163-74, 2003 (PubMed).

Galvani, Courbeyrette, Agez et al.: "In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells." in: Molecular and cellular biology, Vol. 28, Issue 11, pp. 3672-85, 2008 (PubMed).

Alternatives for antigen "CAF-1 Subunit", type "Antibodies"
Hosts (10), (3)
Reactivities (11), (1), (1), (1), (1)
Applications (11), (10), (6), (3), (2), (1), (1)
Epitopes (1)
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