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Details for Product No. ABIN268921

Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody

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Antigen
Synonyms API4, EPR-1, AP14, bir5a, survivin, LOC398389, BIRC5, BIR1, Su2, Survivin, Survivin1, XBIR1, api4, epr-1, svv1, xSurvivin1, xsurv, SIX, Su1, svv2, birc5, xSurvivin, xSurvivin2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN268921
Quantity 25 µL
Price
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Immunogen Recombinant human survivin, full-length.
Clone 32-1
Isotype IgG1
Specificity ABIN153037 is specific for the nuclear form of survivin. The epitope recognized isbetween amino acids 3-19 (1). Species Reactivity: ABIN153037 recognizes human survivin. Other species have not been tested.
Cross-Reactivity Human
Purification Purified
Alternative Name IAP4 / BIRC5
Background Regulated inhibition of programmed cell death (apoptosis) preserves normalhomeostasis and tissue and organ morphogenesis. Aberrations in this processcontribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have beenfound in various species, including human. IAP proteins contain one/three Cys/Hisbaculovirus IAP repeats plus a c-terminus RING finger and are thought to block anevolutionary conserved step in apoptosis.Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expressionis turned off during fetal development and is not found in non-neoplastic adult humantissues. Survivin becomes abundantly re-expressed in transformed cells and in all ofthe most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division,governing a checkpoint involved in cytokinesis while also suppressing apoptosis.Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) ofadult rats following traumatic brain injury. Survivin has been found co-expressed withNeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affectregulation of neural cell proliferative responses after brain injury. Alternate Names: anti-API4 antibody, anti-Apoptosis Inhibitor 4 antibody, anti-Apoptosis inhibitor survivinantibody, anti-Baculoviral IAP repeat containing 5 antibody, anti-BIRC 5 antibody,anti-EPR 1 antibody, anti-IAP4 antibody, anti-SVV antibody, anti-TIAP antibody,anti-BIRC5 antibody.
Gene ID 332
Research Area Cancer, Apoptosis/Necrosis, Neurology
Application Notes By Western blot, this antibody recognizes a band at ~16.5 kDa representing survivin (1).Suggested working dilutions: *Western Blot - 1:1,000, ImmunohistochemistryImmunofluorescence - (see ref. 1)
Restrictions For Research Use only
Format Liquid
Concentration 1.9 mg/ml
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
Ambrosini, Adida, Sirugo et al.: "Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 11177-82, 1998 (PubMed).

Li, Ambrosini, Chu et al.: "Control of apoptosis and mitotic spindle checkpoint by survivin." in: Nature, Vol. 396, Issue 6711, pp. 580-4, 1999 (PubMed).

Li, Ackermann, Bennett et al.: "Pleiotropic cell-division defects and apoptosis induced by interference with survivin function." in: Nature cell biology, Vol. 1, Issue 8, pp. 461-6, 2000 (PubMed).

Grossman, McNiff, Li et al.: "Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma." in: The Journal of investigative dermatology, Vol. 113, Issue 6, pp. 1076-81, 2000 (PubMed).

Adida, Haioun, Gaulard et al.: "Prognostic significance of survivin expression in diffuse large B-cell lymphomas." in: Blood, Vol. 96, Issue 5, pp. 1921-5, 2000 (PubMed).

Fortugno, Wall, Giodini et al.: "Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function." in: Journal of cell science, Vol. 115, Issue Pt 3, pp. 575-85, 2002 (PubMed).

Giodini, Kallio, Wall et al.: "Regulation of microtubule stability and mitotic progression by survivin." in: Cancer research, Vol. 62, Issue 9, pp. 2462-7, 2002 (PubMed).

Alternatives for antigen "Baculoviral IAP Repeat-Containing 5 (BIRC5)", type "Antibodies"
Hosts (96), (32), (3)
Reactivities (109), (45), (24), (9), (4), (3), (3), (3), (2)
Applications (104), (49), (48), (30), (23), (17), (11), (10), (5), (2), (1), (1), (1), (1), (1), (1)
Conjugates (5), (5), (5)
Epitopes (29), (8), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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