Integrin Alpha2b antibody

Catalog No. ABIN2689249

Product Details anti-Integrin Alpha2b Antibody

Target: Integrin Alpha2b (CD41)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Cytotoxicity Test (CyTox)

Brand: BD Pharmingen™

Characteristics: The MWReg30 antibody reacts with glycoprotein (gp) IIb, also called integrin αIIb chain (CD41), that associates with integrin β3 chain (gpIIIa or CD61) to form the gpIIb/IIIa (CD41/CD61) complex. CD41/CD61 is expressed on platelets, megakaryocytes, and early hematopoietic progenitors. The integrin complex binds to fibrinogen, fibronectin, vitronectin, von Willebrand factor, and thrombospondin. It is important for platelet adhesion and aggregation, and it may play a role in osteolytic tumor metastasis. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

BD Pharmingen™ Purified Rat Anti-Mouse CD41 - Purified - Clone MWReg30 - Isotype Rat IgG1, κ - Reactivity Ms - 0.5 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse Platelets

Clone: MWReg30

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-Integrin Alpha2b antibody (ABIN2689249)

Bakewell, Nestor, Prasad, Tomasson, Dowland, Mehrotra, Scarborough, Kanter, Abe, Phillips, Weilbaecher: "Platelet and osteoclast beta3 integrins are critical for bone metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 24, pp. 14205-10, (2003) (PubMed).

Ferkowicz, Starr, Xie, Li, Johnson, Shelley, Morrison, Yoder: "CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo." in: Development (Cambridge, England), Vol. 130, Issue 18, pp. 4393-403, (2003) (PubMed).

Nieswandt, Echtenacher, Wachs, Schröder, Gessner, Schmidt, Grau, Männel: "Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice." in: Blood, Vol. 94, Issue 2, pp. 684-93, (1999) (PubMed).

Kieffer, Phillips: "Platelet membrane glycoproteins: functions in cellular interactions." in: Annual review of cell biology, Vol. 6, pp. 329-57, (1991) (PubMed).

Phillips, Charo, Scarborough: "GPIIb-IIIa: the responsive integrin." in: Cell, Vol. 65, Issue 3, pp. 359-62, (1991) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41 (CD41 Products)

Synonyms: AI172977 antibody, CD41 antibody, CD41B antibody, GpIIb antibody, alphaIIb antibody, BDPLT16 antibody, BDPLT2 antibody, GP2B antibody, GPIIb antibody, GT antibody, GTA antibody, HPA3 antibody, integrin alpha 2b antibody, integrin subunit alpha 2b antibody, Itga2b antibody, ITGA2B antibody

Background: Synonyms: Integrin α IIb chain

Pathways: Integrin Complex