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Details for Product No. ABIN268929

Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) antibody

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Antigen
Synonyms CD, ACUG, BLAU, IBD1, NLRC2, NOD2B, CARD15, CLR16.3, PSORAS1, Card15, F830032C23Rik, Nlrc2
Reactivity
»Alternatives Human, Monkey
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN268929
Quantity 25 µL
Price
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Immunogen A synthetic peptide made to the C-terminal region of the human NOD2 protein sequence(between residues 1,000-1,040).
Specificity This antibody is specific for NOD2 protein. Species Reactivity: This antibody reacts with human protein. Other species have not been tested. Theimmunogen used for this antibody production has 100% homology with human andmonkey protein.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name CARD15 / NOD2
Background NOD2 is a member of the apoptosis regulating protein family that includes caspaserecruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs,a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor forbacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) andCrohn's disease. Alternate Names: anti-NOD-2 antibody, anti-NOD 2 antibody, anti-CARD15 antibody, anti-Caspaserecruitment domain protein 15 antibody, anti-IBD1 antibody, anti-Inflammatory Boweldisease protein 1 antibody.
Gene ID 64127
Research Area Signaling, Transcription Factors
Application Notes Suggested working dilutions: Western Blot 0.5-2 ug/ml
Restrictions For Research Use only
Format Liquid
Concentration 0.87 mg/ml
Buffer Tris-glycine buffer containing 150mM NaCl. Preservative: 0.05% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Hisamatsu, Suzuki, Reinecker et al.: "CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells." in: Gastroenterology, Vol. 124, Issue 4, pp. 993-1000, 2003 (PubMed).

Abbott, Wilkins, Asara et al.: "The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO." in: Current biology : CB, Vol. 14, Issue 24, pp. 2217-27, 2004 (PubMed).

Till, Rosenstiel, Braeutigam et al.: "A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion." in: Journal of cell science, Vol. 121, Issue Pt 4, pp. 487-95, 2008 (PubMed).

Alternatives for antigen "Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2)", type "Antibodies"
Hosts (66), (23), (6), (5)
Reactivities (93), (17), (12), (12), (12), (11), (4)
Applications (90), (32), (28), (27), (15), (9), (9), (9), (3), (1), (1), (1)
Conjugates (5), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (21), (9), (8), (4), (2), (2), (1)
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