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Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) antibody

Antigen

Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2)
Synonyms CD, ACUG, BLAU, IBD1, NLRC2, NOD2B, CARD15, CLR16.3, PSORAS1
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Monkey
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN268929
Quantity 25 µL  (0.87 mg/ml)  (Variants)
Price Product not available in this region.
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Additional Information
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Alternative name CARD15 / NOD2
Gene ID 64127
Immunogen A synthetic peptide made to the C-terminal region of the human NOD2 protein sequence(between residues 1,000-1,040).
Cross-Reactivity Human
Description NOD2 is a member of the apoptosis regulating protein family that includes caspaserecruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs,a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor forbacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) andCrohn's disease. Alternate Names: anti-NOD-2 antibody, anti-NOD 2 antibody, anti-CARD15 antibody, anti-Caspaserecruitment domain protein 15 antibody, anti-IBD1 antibody, anti-Inflammatory Boweldisease protein 1 antibody.
Specificity This antibody is specific for NOD2 protein. Species Reactivity: This antibody reacts with human protein. Other species have not been tested. Theimmunogen used for this antibody production has 100% homology with human andmonkey protein.

Application Details
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Application Notes Suggested working dilutions: Western Blot 0.5-2 ug/ml
Concentration 0.87 mg/ml
Purification Affinity Purified
Buffer Tris-glycine buffer containing 150mM NaCl. Preservative: 0.05% Sodium Azide.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Research Area Signaling, Transcription Factors
Restrictions For Research Use only

Publications
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Hisamatsu, Suzuki, Reinecker et al.: "CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells." in: Gastroenterology, Vol. 124, Issue 4, pp. 993-1000, 2003 (PubMed).

Abbott, Wilkins, Asara et al.: "The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO." in: Current biology : CB, Vol. 14, Issue 24, pp. 2217-27, 2004 (PubMed).

Till, Rosenstiel, Braeutigam et al.: "A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion." in: Journal of cell science, Vol. 121, Issue Pt 4, pp. 487-95, 2008 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2)", type "Antibodies"
Hosts Rabbit (48), Mouse (6), Goat (4), Rat (2)
Reactivities Human (56), Mouse (Murine) (21), Dog (Canine) (18), Pig (Porcine) (18), Rat (Rattus) (18), Cow (Bovine) (17), Horse (Equine) (17), Monkey (1)
Applications Western Blotting (WB) (44), ELISA (20), Immunofluorescence (IF) (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (14), Immunoprecipitation (IP) (10), Immunocytochemistry (ICC) (9), Immunohistochemistry (IHC) (3), Flow Cytometry (FACS) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (9), Center (4), N-Term (4), Internal Region (3), AA 125-140 (2), AA 28-301 (2), AA 582-600 (2), Internal Region,AA 427-457 (1), Internal Region,AA 441-471 (1)