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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2) antibody
|Synonyms||CD, ACUG, BLAU, IBD1, NLRC2, NOD2B, CARD15, CLR16.3, PSORAS1|
Alternatives Western Blotting (WB)
|3 references available|
|Quantity||25 µL (0.87 mg/ml) (Variants)|
|Price||Product not available in this region.|
|Alternative name||CARD15 / NOD2|
|Immunogen||A synthetic peptide made to the C-terminal region of the human NOD2 protein sequence(between residues 1,000-1,040).|
|Description||NOD2 is a member of the apoptosis regulating protein family that includes caspaserecruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs,a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor forbacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) andCrohn's disease. Alternate Names: anti-NOD-2 antibody, anti-NOD 2 antibody, anti-CARD15 antibody, anti-Caspaserecruitment domain protein 15 antibody, anti-IBD1 antibody, anti-Inflammatory Boweldisease protein 1 antibody.|
|Specificity||This antibody is specific for NOD2 protein. Species Reactivity: This antibody reacts with human protein. Other species have not been tested. Theimmunogen used for this antibody production has 100% homology with human andmonkey protein.|
|Application Notes||Suggested working dilutions: Western Blot 0.5-2 ug/ml|
|Buffer||Tris-glycine buffer containing 150mM NaCl. Preservative: 0.05% Sodium Azide.|
|Storage||Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.|
|Research Area||Signaling, Transcription Factors|
|Restrictions||For Research Use only|
Hisamatsu, Suzuki, Reinecker et al.: "CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells." in: Gastroenterology, Vol. 124, Issue 4, pp. 993-1000, 2003 (PubMed).
Abbott, Wilkins, Asara et al.: "The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO." in: Current biology : CB, Vol. 14, Issue 24, pp. 2217-27, 2004 (PubMed).
Till, Rosenstiel, Braeutigam et al.: "A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion." in: Journal of cell science, Vol. 121, Issue Pt 4, pp. 487-95, 2008 (PubMed).