CEACAM6 antibody

Catalog No. ABIN2689376

Product Details anti-CEACAM6 Antibody

Target: CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CEACAM6 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Brand: BD Pharmingen™

Characteristics: Reacts with two glycosylphosphatidylinositol-anchored glycoprotein present on granulocytes. Antibody B6.2 was studied as recognizing CD66c in the VI Human Leukocyte Differentiation Antigen workshop. CD66 antigens also known as the carcinoembryonic antigen (CEA) family of molecules, are closely related to the immunoglobulin super family of glycoproteins. Studies on CD66 Molecules suggest a potential adhesion function in vivo. These molecules exhibit both homophilic and heterophilic adhesion. CEA family members may be involved in transmembrane signalling and activation of neutrophils. This clone has been found to be N-terminal domain reactive, reacted preferentially with the native protein and were conformationally dependent. Profile of peripheral blood granulocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD66c - Purified - Clone B6.2/CD66 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: B6-2-CD66

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-CEACAM6 antibody (ABIN2689376)

Watt, Teixeira, Zhou, Doyonnas, Zhang, Grunert, Blumberg, Kuroki, Skubitz, Bates: "Homophilic adhesion of human CEACAM1 involves N-terminal domain interactions: structural analysis of the binding site." in: Blood, Vol. 98, Issue 5, pp. 1469-79, (2001) (PubMed).

Skubitz, Campbell, Ahmed, Skubitz: "CD66 family members are associated with tyrosine kinase activity in human neutrophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 11, pp. 5382-90, (1995) (PubMed).

Kuroki, Arakawa, Matsuo, Oikawa, Misumi, Nakazato, Matsuoka: "Molecular cloning of nonspecific cross-reacting antigens in human granulocytes." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 11810-7, (1991) (PubMed).

Thompson, Grunert, Zimmermann: "Carcinoembryonic antigen gene family: molecular biology and clinical perspectives." in: Journal of clinical laboratory analysis, Vol. 5, Issue 5, pp. 344-66, (1991) (PubMed).

Szpak, Johnston, Lottich, Kufe, Thor, Schlom: "Patterns of reactivity of four novel monoclonal antibodies (B72.3, DF3, B1.1 and B6.2) with cells in human malignant and benign effusions." in: Acta cytologica, Vol. 28, Issue 4, pp. 356-67, (1984) (PubMed).

Target Details for CEACAM6

Target: CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6))

Alternative Name: CD66c (CEACAM6 Products)

Synonyms: CD66c antibody, CEAL antibody, NCA antibody, carcinoembryonic antigen-related cell adhesion molecule 6 antibody, carcinoembryonic antigen related cell adhesion molecule 6 antibody, Ceacam6 antibody, CEACAM6 antibody

Background: Synonyms: CEA, carcinoembryonic antigen