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MHC, Class I (Heavy Chain) antibody

Details for Product No. ABIN268938, Supplier: Log in to see
Antigen
  • H-2K
  • H-2K(d)
  • H2-K
  • K-f
  • Y-FA
  • YFV
  • histocompatibility 2, K1, K region
  • MHC class I antigen
  • MHC class I antigen YF5
  • H2-K1
  • OVAR
  • YF5
Epitope
Heavy Chain
50
38
16
Reactivity
Human, Primate
153
146
76
31
27
26
24
24
23
22
9
3
3
1
1
Host
Mouse
275
36
32
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
38
35
24
14
14
12
10
10
10
10
10
10
10
10
9
7
6
6
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), Western Blotting (WB)
282
114
78
54
48
43
31
26
15
11
11
5
4
3
2
2
2
2
1
Options
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Immunogen Recombinant human HLA-E denatured heavy chain.
Clone MEM-E-02
Isotype IgG1
Specificity The antibody MEM-E/02 specifically reacts with denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib, nonclassical) and it is expressed on the surface of all human cell types.
Purification Protein A purified
Alternative Name MHC Class I
Background Gene Symbol: HLA-E
Gene ID 3133
Research Area Immunology, Major Histocompatibility Complex (MHC)
Application Notes Western Blot 1:1000, Immunohistochemistry, Immunohistochemistry-Paraffin 5-10 μg/mLPredicted molecular weight: 43 kDa. Immunohistochemistry-Paraffin Heat antigen retrieval (sodium citrate), incubation with mAb: 1 hour/ RT, detection DAB
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS ( pH 7.4)
Buffer contains: 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment Store at 4°C. Do not freeze.
Product cited in: Ye, Li, Luo, Huang, Chen, Zhang, Cui, Zeng, Li: "Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma." in: Oncotarget, Vol. 5, Issue 14, pp. 5439-52, 2014 (PubMed). (Sample species: Human). Further details: Western Blotting

Mavilio, Lombardo, Kinter, Fogli, La Sala, Ortolano, Farschi, Follmann, Gregg, Kovacs, Marcenaro, Pende, Moretta, Fauci: "Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection." in: The Journal of experimental medicine, Vol. 203, Issue 10, pp. 2339-50, 2006 (PubMed).

Menier, Saez, Horejsi, Martinozzi, Krawice-Radanne, Bruel, Le Danff, Reboul, Hilgert, Rabreau, Larrad, Pla, Carosella, Rouas-Freiss: "Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules." in: Human immunology, Vol. 64, Issue 3, pp. 315-26, 2003 (PubMed).