C5AR1 antibody

Catalog No. ABIN2689428

Product Details anti-C5AR1 Antibody

Target: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This C5AR1 antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Brand: BD Pharmingen™

Characteristics: The human C5a receptor (C5aR) is expressed on granulocytes, monocytes, macrophages mast cells human cell lines of myeloid origin, and certain cell types in several organs, including dendritic cells of secondary lymphoid organs, liver hepatocytes, lung bronchial and alveolar epithelial cells, lung vascular smooth muscle, endothelial cells astrocytes, microglia, and fibroblast-like cells of the brain. The C85-2506 is a rabbit monoclonal antibody generated by fusion of splenocytes from rabbits immunized with human C5aR peptides and the rabbit fusion partner 240E-1. C85-2506 staining on dendritic cells and granulocytes of human tonsil paraffin sections.

BD Pharmingen™ Purified Rabbit Anti-Human CD88 - Purified - Clone C85-2506 - Isotype Rabbit IgG - Reactivity Hu - 1 mL

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: C85

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-C5AR1 antibody (ABIN2689428)

Fayyazi, Sandau, Duong, Götze, Radzun, Schweyer, Soruri, Zwirner: "C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells." in: The American journal of pathology, Vol. 154, Issue 2, pp. 495-501, (1999) (PubMed).

Paradisis, Campbell, Barnum: "Elevated complement C5a receptor expression on neurons and glia in astrocyte-targeted interleukin-3 transgenic mice." in: Glia, Vol. 24, Issue 3, pp. 338-45, (1999) (PubMed).

Nataf, Davoust, Barnum: "Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis." in: Journal of neuroimmunology, Vol. 91, Issue 1-2, pp. 147-55, (1998) (PubMed).

Stahel, Frei, Eugster, Fontana, Hummel, Wetsel, Ames, Barnum: "TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 2, pp. 861-9, (1997) (PubMed).

Morelli, Larregina, Chuluyán, Kolkowski, Fainboim: "Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells." in: Immunology, Vol. 89, Issue 1, pp. 126-34, (1996) (PubMed).

Füreder, Agis, Willheim, Bankl, Maier, Kishi, Müller, Czerwenka, Radaszkiewicz, Butterfield, Klappacher, Sperr, Oppermann, Lechner, Valent: "Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 6, pp. 3152-60, (1995) (PubMed).

Haviland, McCoy, Whitehead, Akama, Molmenti, Brown, Haviland, Parks, Perlmutter, Wetsel: "Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1861-9, (1995) (PubMed).

Spieker-Polet, Sethupathi, Yam, Knight: "Rabbit monoclonal antibodies: generating a fusion partner to produce rabbit-rabbit hybridomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 20, pp. 9348-52, (1995) (PubMed).

Wetsel: "Expression of the complement C5a anaphylatoxin receptor (C5aR) on non-myeloid cells." in: Immunology letters, Vol. 44, Issue 2-3, pp. 183-7, (1995) (PubMed).

Target Details for C5AR1

Target: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Alternative Name: CD88 (C5AR1 Products)

Synonyms: C5A antibody, C5AR antibody, C5R1 antibody, CD88 antibody, C5aR antibody, C5r1 antibody, Cd88 antibody, D7Msu1 antibody, GPR77 antibody, complement C5a receptor 1 antibody, complement component 5a receptor 1 antibody, C5AR1 antibody, C5ar1 antibody, c5ar1 antibody

Background: Synonyms: C5a Receptor

Pathways: Complement System