FAS antibody

Catalog No. ABIN2689464

Product Details anti-FAS Antibody

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FAS antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func), Fluorescence Microscopy (FM)

Brand: BD Pharmingen™

Characteristics: Reacts with a 45 kD type I membrane molecule also known as APO-1, or Fas antigen. CD95 belongs to the tumor necrosis factor receptor (TNF-R) family of proteins and is expressed on various cells, including activated T cells and B cells. The interaction of CD95, Fas antigen, with Fas ligand is one of the many mechanisms that lead to apoptosis or programmed cell death. The interaction of CD95 expressing target cells with Fas ligand on cytotoxic T cells induces an apoptotic signal leading to target cell death. It has been reported that apoptosis is the mechanism used by the immune system in clonal deletion of self-reactive T cells during embryological development. Jurkat cells treated for 6 hours with CD95 (EOS9.1) Jurkat cells treated for 6 hours with mouse IgM isotype control

BD Pharmingen™ Purified Mouse Anti-Human CD95 - Purified - Clone EOS9.1 - Isotype Mouse IgM, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: EOS9-1

Isotype: IgM kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing no preservative.

Preservative: Without preservative

Handling Advice: This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-FAS antibody (ABIN2689464)

Krammer, Dhein, Walczak, Behrmann, Mariani, Matiba, Fath, Daniel, Knipping, Westendorp: "The role of APO-1-mediated apoptosis in the immune system." in: Immunological reviews, Vol. 142, pp. 175-91, (1995) (PubMed).

Nagata, Golstein: "The Fas death factor." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1449-56, (1995) (PubMed).

Rouvier, Luciani, Golstein: "Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity." in: The Journal of experimental medicine, Vol. 177, Issue 1, pp. 195-200, (1993) (PubMed).

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: CD95 (FAS Products)

Synonyms: ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody

Background: Synonyms: Fas/APO-1

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity