Vimentin (VIM) antibody

Details for Product No. ABIN268950
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Antigen
Synonyms CTRCT30, cb28, VIM, Vimentin, vim, vime
Reactivity
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(443), (166), (154), (85), (78), (54), (44), (18), (12), (11), (10), (9), (6), (5), (5), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(229), (229), (25), (9), (7), (5), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(17), (15), (9), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB), ELISA
(364), (161), (145), (144), (90), (87), (48), (44), (40), (37), (6), (3), (3), (3), (3), (2), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN268950
Quantity 0.1 mg
Price
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Immunogen Pellet of pig brain cold stable proteins after depolymerization of microtubules.
Clone VI-01
Isotype IgM
Specificity Besides reactivity with vimentin, this antibody also cross-reacts with smooth muscledesmin. A positive reaction is also found on thyroid folicular cells and severalmesothelial cells. Species Reactivity: Cross-reacts with all species (recognized epitope conserved within all species). Localization: Cytoplasmic.
Alternative Name Vimentin
Background Vimentin is the major subunit protein of the intermediate filaments of mesenchymalcells. It is believed to be involved with the intracellular transport of proteins between thenucleus and plasma membrane. Vimentin has been implicated to be involved in the rateof steroid synthesis via its role as a storage network for steroidogenic cholesterolcontaining lipid droplets. Vimentin phosphorylation by a protein kinase causes thebreakdown of intermediate filaments and activation of an ATP and myosin light chaindependent contractile event. This results in cytoskeletal changes that facilitate theinteraction of the lipid droplets within mitochondria, and subsequent transport ofcholesterol to the organelles leading to an increase in steroid synthesis.Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural,muscle and fibroblast origin) compared to carcinomas which are generally negative.Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentinantibodies are thus of value in the differential diagnosis of undifferentiated neoplasmsand malignant tumors. They are generally used with a panel of other antibodiesincluding those recognizing cytokeratins, lymphoid markers, S100, desmin andneurofilaments. Alternate Names: anti-FLJ36605 antibody, anti-VIM antibody.
Research Area Lineage Markers, Cytoskeleton, Neural Stem Cell marker, Cell/Tissue Markers
Restrictions For Research Use only
Buffer In PBS with 15mM Sodium Azide. pH 7.4
Preservative Sodium azide
Storage -20 °C
General Dráberová, Dráber, Havlícek et al.: "A common antigenic determinant of vimentin and desmin defined by monoclonal antibody." in: Folia biologica, Vol. 32, Issue 5, pp. 295-303, 1989 (PubMed).

Lukás, Dráber, Bucek et al.: "Expression of vimentin and glial fibrillary acidic protein in human developing spinal cord." in: The Histochemical journal, Vol. 21, Issue 12, pp. 693-701, 1990 (PubMed).

Lukás, Dráber, Bucek et al.: "Expression of phosphorylated high molecular weight neurofilament protein (NF-H) and vimentin in human developing dorsal root ganglia and spinal cord." in: Histochemistry, Vol. 100, Issue 6, pp. 495-502, 1994 (PubMed).

Rankin, Tomaszewski, Haase: "Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor." in: Cancer research, Vol. 66, Issue 5, pp. 2576-83, 2006 (PubMed).

Deramaudt, Takaoka, Upadhyay et al.: "N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4185-200, 2006 (PubMed).

Hosts (229), (229), (25), (9), (7), (5), (4)
Reactivities (443), (166), (154), (85), (78), (54), (44), (18), (12), (11), (10), (9), (6), (5), (5), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (364), (161), (145), (144), (90), (87), (48), (44), (40), (37), (6), (3), (3), (3), (3), (2), (2), (1), (1)
Conjugates (17), (15), (9), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1)
Epitopes (20), (18), (16), (15), (8), (8), (6), (5), (5), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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