Galectin 3 antibody

Catalog No. ABIN2689513

Product Details anti-Galectin 3 Antibody

Target: Galectin 3 (LGALS3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Galectin 3 antibody is un-conjugated

Application: Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Intracellular Staining (ICS)

Brand: BD Pharmingen™

Characteristics: Reacts with Galectin-3, a 30 kDa protein, a member of a newly defined family of β-galactoside-binding animal lectins. It has been previously referred to as IgE-binding protein (εBP) and carbohydrate-binding protein 35 (CBP35). It is expressed on many tissues and cell types. Galectin-3 can be found in the nucleus and/or cytoplasm, on the cell surface and in the extra cellular matrix. Its function has been found to be diverse. It has been reported to be markedly elevated in the nucleus of proliferating cells, suggesting that Galectin-3 may play a role in cell growth regulation. Studies of Galectin-3 on the cell surface have shown it to be a non-integrin, laminin-binding protein, suggesting its role in cell adhesion to basement membranes. Monoclonal antibody B2C10 is suitable for immunohistochemical staining of parafin-embedded tissue sections. Profile of permeabilized peripheral blood monocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human Galectin-3 - Purified - Clone B2C10 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Clone: B2C10

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 4°C.

References for anti-Galectin 3 antibody (ABIN2689513)

Cortegano, del Pozo, Cárdaba, de Andrés, Gallardo, del Amo, Arrieta, Jurado, Palomino, Liu, Lahoz: "Galectin-3 down-regulates IL-5 gene expression on different cell types." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 1, pp. 385-9, (1998) (PubMed).

Liu, Hsu, Zuberi, Hill, Shenhav, Kuwabara, Chen: "Modulation of functional properties of galectin-3 by monoclonal antibodies binding to the non-lectin domains." in: Biochemistry, Vol. 35, Issue 19, pp. 6073-9, (1996) (PubMed).

Mey, Leffler, Hmama, Normier, Revillard: "The animal lectin galectin-3 interacts with bacterial lipopolysaccharides via two independent sites." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 156, Issue 4, pp. 1572-7, (1996) (PubMed).

Cherayil, Weiner, Pillai: "The Mac-2 antigen is a galactose-specific lectin that binds IgE." in: The Journal of experimental medicine, Vol. 170, Issue 6, pp. 1959-72, (1990) (PubMed).

Target Details for Galectin 3

Target: Galectin 3 (LGALS3)

Alternative Name: Galectin-3 (LGALS3 Products)

Synonyms: CBP 35 antibody, Gal-3 antibody, Galectin-3 antibody, leg3 antibody, galactoside-binding antibody, galectin-3 antibody, lectin antibody, soluble antibody, CBP35 antibody, GAL3 antibody, GALBP antibody, GALIG antibody, L31 antibody, LGALS2 antibody, MAC2 antibody, MGC52947 antibody, MGC75803 antibody, LGALS3 antibody, gal-3 antibody, GBP antibody, L-34 antibody, Mac-2 antibody, gal3 antibody, galectin 3 antibody, Galectin-3 antibody, avian beta-defensin 3 antibody, lectin, galactoside-binding, soluble, 3 L homeolog antibody, lectin, galactoside-binding, soluble, 3 antibody, galectin 2 antibody, lectin, galactose binding, soluble 3 antibody, LGALS3 antibody, leg3 antibody, AvBD3 antibody, lgals3.L antibody, lgals3 antibody, LGALS2 antibody, Lgals3 antibody

Target Type: Chemical

Pathways: RTK Signaling