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IL12B antibody
IL12B
Reactivity: Human
ELISA
Host: Mouse
Monoclonal
C8-3
unconjugated
Product Details anti-IL12B Antibody
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Target
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IL12B
(Interleukin 12 beta (IL12B))
Reactivity
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Human
Host
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Mouse
Clonality
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Monoclonal
Conjugate
All conjugates for IL12B antibodies
This IL12B antibody is un-conjugated
Application
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ELISA
Brand
BD Pharmingen™
Characteristics
The C8.3 antibody reacts with human IL-12 p40 subunit but not IL-12 p70 heterodimer or IL-12 p35 monomer. The immunogen used to generate the C8.3 hybridoma was the purified p40 subunit of human IL-12. The C8.3 antibody has been reported not to bind p40 chain when it is complexed to p35 (i.e., the p70 heterodimer). The combination of anti-p40 antibodies, C8.3 and C8.6 , has been reported to yield an assay for detecting only free p40 chain, and specifically not the p70 heterodimer. It has been reported that activated PBMC produce an excess of the free p40 protein over the p70 heterodimer. BD Pharmingen™ Purified Mouse Anti-Human IL-12 (p40) - Purified - Clone C8.3 - Isotype Mouse IgG1, κ - Reactivity Hu - 1 mg
Purification
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen
Purified human IL-12 p40 subunit
Clone
C8-3
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
References for anti-IL12B antibody (ABIN2689727)
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DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg : "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. " in: The Journal of experimental medicine , Vol. 176 , Issue 5 , pp. 1387-98 , (1992 ) (PubMed ).
Target Details for IL12B
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Target
IL12B
(Interleukin 12 beta (IL12B))
Alternative Name
IL-12 p40 (IL12B Products )
Synonyms
CLMF antibody, CLMF2 antibody, IL-12B antibody, NKSF antibody, NKSF2 antibody, p40 antibody, Il-12b antibody, Il12p40 antibody, Il-12p40 antibody, Il12 antibody, IL-12p40 antibody, IL-12 antibody, IL-12 p40 antibody, il12b antibody, il12p40.b antibody, zgc:152789 antibody, IL-12.p40 antibody, IL12p40 antibody, IL12B antibody, CLMF p40 antibody, interleukin 12B antibody, interleukin 12b antibody, interleukin 12Ba antibody, IL12B antibody, Il12b antibody, il12ba antibody
Pathways
JAK-STAT Signaling , Cellular Response to Molecule of Bacterial Origin , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Activated T Cell Proliferation
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