eacts with leukocyte associated immunoglobulin-like receptor-1 (LAIR-1), a 32 kDa transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. It is expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 recruits SHP-1 and SHP-2 tyrosine phosphatases upon activation, and cross-linking of the LAIR-1 Molecule on NK cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize MHC class I molecules and thus represents a novel MHC class I-independent mechanism of NK cell regulation. Other studies report other roles of LAIR-1 in cell differentiation. Profile of peripheral blood lymphocytes analyzed by flow cytometry
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store undiluted at 4°C.
Xu, Zhao, Zhao: "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17440-6, (2000) (PubMed).
Meyaard, Adema, Chang, Woollatt, Sutherland, Lanier, Phillips: "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes." in: Immunity, Vol. 7, Issue 2, pp. 283-90, (1997) (PubMed).