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Perforin 1 antibody

PRF1 Reactivity: Human, Cow WB, IP, IF, IHC (fro), IHC (f), ICS Host: Mouse Monoclonal deltaG9 unconjugated
Catalog No. ABIN2689879
  • Target See all Perforin 1 (PRF1) Antibodies
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Reactivity
    • 80
    • 26
    • 10
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Human, Cow
    Host
    • 57
    • 41
    • 4
    Mouse
    Clonality
    • 58
    • 44
    Monoclonal
    Conjugate
    • 58
    • 13
    • 11
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Perforin 1 antibody is un-conjugated
    Application
    • 50
    • 40
    • 30
    • 20
    • 15
    • 10
    • 7
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Intracellular Staining (ICS)
    Brand
    BD Pharmingen™
    Characteristics
    Perforin has a key role in cell-mediated cytotoxicity. It is a 70 kDa cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. CTLs are involved in eliminating virally infected cells, in anti-tumor immune responses, in allograft rejections, and in some autoimmune diseases. NK cells are important for tumor surveillance and destruction and are involved in allograft rejections. Cytotoxic cells release the contents of their cytotoxic granules, including perforin upon recognition of their target cell. In the presence of calcium, perforin forms transmembrane channels or pores in the membrane of the target cell leading to a cell death that resembles apoptosis. The ability to detect perforin-positive cells with specific antibody should be useful in identifying and understanding perforin-mediated reactions.

    BD Pharmingen™ Purified Mouse Anti-Human Perforin - Purified - Clone δG9 - Isotype Mouse IgG2b, κ - Reactivity Hu, Cow - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Purified Granules from the Human Lymphoma Cell Line YT
    Clone
    DeltaG9
    Isotype
    IgG2b kappa
    Top Product
    Discover our top product PRF1 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Target
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Alternative Name
    Perforin (PRF1 Products)
    Synonyms
    FLH2 antibody, HPLH2 antibody, P1 antibody, PFN1 antibody, PFP antibody, PRF1 antibody, Pfn antibody, Pfp antibody, Prf-1 antibody, Cyta antibody, RATCYTA antibody, LOC443187 antibody, perforin antibody, prf1 antibody, cytolysin antibody, perforin-1 antibody, perforin-1-like antibody, perforin 1 antibody, perforin 1 (pore forming protein) antibody, perforin antibody, perforin 1 L homeolog antibody, PRF1 antibody, Prf1 antibody, LOC443187 antibody, prf1 antibody, prf1.L antibody
    Background
    Synonyms: PRF1, P1, PERF, PFN1, PFP, Perforin-1, Cytolysin, FLH2, HPLH2
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis
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