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Histone Deacetylase 4 (HDAC4) (AA 14-28), (C-Term) antibody

Details for Product No. ABIN269450, Supplier: Login to see
Antigen
  • CG1770
  • DHDAC4
  • Dmel\\CG1770
  • GC1770
  • HDAC
  • HDAC4a
  • dHDAC4
  • dmHDA405
  • hdac4
  • dana_GLEANR_19966
  • DanaGF18710
  • GF18710
  • HDAC4
  • AHO3
  • BDMR
  • HA6116
  • HD4
  • HDAC-4
  • HDAC-A
  • HDACA
  • 4932408F19Rik
  • AI047285
  • wu:fa96d08
  • wu:fc56f08
  • zgc:152701
Epitope
C-Term, AA 14-28
47
34
20
15
10
10
6
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
260
102
71
8
3
3
2
2
1
1
1
1
1
Host
Rabbit
227
39
2
Clonality
Polyclonal
Conjugate
Un-conjugated
10
9
9
4
4
4
3
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Microarray (MA), Western Blotting (WB)
236
85
50
32
30
22
13
12
11
5
3
1
1
1
1
Supplier
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Immunogen Synthetic peptide: DQPVELLNPARVNHM with C-terminal added lysine, conjugated to KLH, corresponding to amino acids 14-28 of Human HDAC4
Isotype IgG
Specificity HDAC4
Cross-Reactivity (Details) Expected to cross-react with Chicken (93% identity with immunogen) due to sequence homology. Not yet tested in other species.
Purification affinity purified
Alternative Name HDAC4 (HDAC4 Antibody Abstract)
Background Chromatin is a highly specialized structure composed of tightly compacted chromosomalDNA. Gene expression within the nucleus is controlled, in part, by a host of proteincomplexes which continuously pack and unpack the chromosomal DNA. One of theknown mechanisms of this packing and unpacking process involves the acetylation anddeacetylation of the histone proteins comprising the nucleosomal core. Acetylatedhistone proteins confer accessibility of the DNA template to the transcriptionalmachinery for expression. Histone deacetylases (HDACs) are chromatin remodelingfactors that deacetylate histone proteins and thus, may act as transcriptional repressors.HDACs are classified by their sequence homology to the yeast HDACs and there arecurrently 2 classes. Class I proteins are related to Rpd3 and members of class IIresemble Hda1p. Alternate Names: Anti-HA6116 antibody, Anti-HD 4 antibody Anti-HD4 antibody, Anti-HDAC 4 antibody,Anti-HDAC A antibody, Anti-HDACA antibody, Anti-Histone Deacetylase 4 antibody,Anti-Histone Deacetylase A antibody, Anti-KIAA0288 antibody.
Gene Symbol: HDAC4
Gene ID 9759, 208727, 363287
Research Area Cardiovascular, Hypertrophy, Cancer, DNA/RNA, Transcription Factors
Pathways
Application Notes Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:250, Immunoprecipitation 10-20 µg, Microarray, Western Blot 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer 1 % BSA, 0.01 M PBS. pH 7.4, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Product cited in: Geng, Cuneo, Fu et al.: "Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer." in: Cancer research, Vol. 66, Issue 23, pp. 11298-304, 2006 (PubMed).

Background publications Fischle, Kiermer, Dequiedt et al.: "The emerging role of class II histone deacetylases." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 79, Issue 3, pp. 337-48, 2001 (PubMed).

Khochbin, Verdel, Lemercier et al.: "Functional significance of histone deacetylase diversity." in: Current opinion in genetics & development, Vol. 11, Issue 2, pp. 162-6, 2001 (PubMed).

Wang, Bertos, Vezmar et al.: "HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor." in: Molecular and cellular biology, Vol. 19, Issue 11, pp. 7816-27, 1999 (PubMed).

Grozinger, Hassig, Schreiber: "Three proteins define a class of human histone deacetylases related to yeast Hda1p." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 9, pp. 4868-73, 1999 (PubMed).