Suppressor of Cytokine Signaling 2 (SOCS2) (AA 184-198) antibody

Details for Product No. ABIN269520
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Antigen
Synonyms si:dkey-202b22.1, socs2, cis2, ssi2, cish2, ssi-2, socs-2, stati2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, 8030460M17, AI527257, AW108012, D130043N08Rik, JAB, hg, Socs-2
Epitope
AA 184-198
(13), (6), (4), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(52), (23), (22), (12), (12), (12)
Host
Rabbit
(49), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(30), (14), (14), (11), (10), (3), (1), (1), (1)
Pubmed 8 references available
Quantity 0.05 mg
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Catalog No. ABIN269520
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Immunogen Synthetic peptide (PTRLKDYLEEYKFQV) correspondingto amino acids 184-198 of human, rat and mouse SOCS 2 (NP_003868)
Isotype IgG
Specificity SOCS2
Cross-Reactivity (Details) Not yet tested in other species.
Purification affinity purified
Alternative Name SOCS2 / CIS2
Background Accumulating evidence demonstrates that cytokine receptorsignaling is negativelyregulated by a family of Srchomology 2 domain-containing adaptor moleculesTermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members ofSOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS.Structurally the SOCS proteins are composed of an Nterminalregion of variable lengthand amino acidcomposition, a central SH2 domain, and a previouslyunrecognizedC-terminal motif that we have called the SOCS box. The SOCS proteins appear to formpart of aclassical negative feed back loop that regulates cytokinesignal transduction viaa STAT induced transcriptionalmechanism. Transcription of each of the SOCSgenesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced,the various members of the SOCSfamily appear to inhibit signaling in different ways.SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through itsability to influence the GH / IGF 1axis, although they might have overlapping actions. Alternate Names: anti-CIS 2 antibody, anti-CIS2 antibody, anti-Cish 2 antibody, anti-Cish2 antibody,anti-Cytokine inducible SH2 protein 2 antibody, anti-SOCS 2 antibody, anti-SSI 2antibody, anti-SSI2 antibody, anti-STAT induced STAT inhibitor 2 antibody, anti-STATI 2antibody, anti-STATI2 antibody, anti-Suppressor of cytokine signaling 2 antibody.
Gene Symbol: SOCS2
Gene ID 8835
NCBI Accession NP_003868
Application Notes Recommended dilutions: ELISA 1:5000-1:20000, Western Blot 1:500-1:1000
Restrictions For Research Use only
Concentration 0.2 mg/mL
Buffer PBS, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C
General Hilton, Richardson, Alexander et al.: "Twenty proteins containing a C-terminal SOCS box form five structural classes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 1, pp. 114-9, 1998 (PubMed).

Yoshimura: "The CIS family: negative regulators of JAK-STAT signaling." in: Cytokine & growth factor reviews, Vol. 9, Issue 3-4, pp. 197-204, 1999 (PubMed).

Ram, Waxman: "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35553-61, 2000 (PubMed).

Gregorieff, Pyronnet, Sonenberg et al.: "Regulation of SOCS-1 expression by translational repression." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21596-604, 2000 (PubMed).

Krebs, Hilton: "SOCS: physiological suppressors of cytokine signaling." in: Journal of cell science, Vol. 113 ( Pt 16), pp. 2813-9, 2000 (PubMed).

Krebs, Hilton: "SOCS proteins: negative regulators of cytokine signaling." in: Stem cells (Dayton, Ohio), Vol. 19, Issue 5, pp. 378-87, 2001 (PubMed).

Ransome, Turnley: "Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2." in: Neuroscience, Vol. 132, Issue 3, pp. 673-87, 2005 (PubMed).

Inagaki, Lin, Goetz et al.: "Inhibition of growth hormone signaling by the fasting-induced hormone FGF21." in: Cell metabolism, Vol. 8, Issue 1, pp. 77-83, 2008 (PubMed).

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