Suppressor of Cytokine Signaling 2 (SOCS2) antibody

Antigen: Suppressor of Cytokine Signaling 2 (SOCS2)

Synonyms: CIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2, Socs-2, SOCS2, si:dkey-202b22.1, socs2, cis2, ssi2, cish2, ssi-2, socs-2, stati2

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Immunoprecipitation (IP), Western Blotting (WB), ELISA

Catalog no.: ABIN269520

Additional Information

Alternative name: SOCS2 / CIS2

Immunogen: Synthetic peptide (PTRLKDYLEEYKFQV) correspondingto amino acids 184-198 ofhuman, rat and mouse SOCS 2.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Isotype: IgG

Description: Accumulating evidence demonstrates that cytokine receptorsignaling is negativelyregulated by a family of Srchomology 2 domain-containing adaptor moleculesTermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members ofSOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS.Structurally the SOCS proteins are composed of an Nterminalregion of variable lengthand amino acidcomposition, a central SH2 domain, and a previouslyunrecognizedC-terminal motif that we have called the SOCS box. The SOCS proteins appear to formpart of aclassical negative feed back loop that regulates cytokinesignal transduction viaa STAT induced transcriptionalmechanism. Transcription of each of the SOCSgenesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced,the various members of the SOCSfamily appear to inhibit signaling in different ways.SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through itsability to influence the GH / IGF 1axis, although they might have overlapping actions. Alternate Names: anti-CIS 2 antibody, anti-CIS2 antibody, anti-Cish 2 antibody, anti-Cish2 antibody,anti-Cytokine inducible SH2 protein 2 antibody, anti-SOCS 2 antibody, anti-SSI 2antibody, anti-SSI2 antibody, anti-STAT induced STAT inhibitor 2 antibody, anti-STATI 2antibody, anti-STATI2 antibody, anti-Suppressor of cytokine signaling 2 antibody.

Specificity: Species Reactivity: Cross-reacts with Human, Rat and Mouse. Not yet tested in other species.

Application Details

Application Notes: Suggested working dilutions: ELISA 0.1-1.0 ug/ml,immunoprecipitation 1-5 ug,Western Blot 0.5-2.0 ug/ml

Concentration: 0.2 mg/ml

Purification: Aff - Purified

Buffer: PBS. Preservative: 0.05% Sodium Azide

Storage: Store at 4C. Do not freeze.

Restrictions: For Research Use only

Publications

Hilton, Richardson, Alexander et al.: "Twenty proteins containing a C-terminal SOCS box form five structural classes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 1, pp. 114-9, 1998 (PubMed).

Yoshimura: "The CIS family: negative regulators of JAK-STAT signaling." in: Cytokine & growth factor reviews, Vol. 9, Issue 3-4, pp. 197-204, 1999 (PubMed).

Ram, Waxman: "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35553-61, 2000 (PubMed).

Gregorieff, Pyronnet, Sonenberg et al.: "Regulation of SOCS-1 expression by translational repression." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21596-604, 2000 (PubMed).

Krebs, Hilton: "SOCS: physiological suppressors of cytokine signaling." in: Journal of cell science, Vol. 113 ( Pt 16), pp. 2813-9, 2000 (PubMed).

Krebs, Hilton: "SOCS proteins: negative regulators of cytokine signaling." in: Stem cells (Dayton, Ohio), Vol. 19, Issue 5, pp. 378-87, 2001 (PubMed).

Ransome, Turnley: "Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2." in: Neuroscience, Vol. 132, Issue 3, pp. 673-87, 2005 (PubMed).

Inagaki, Lin, Goetz et al.: "Inhibition of growth hormone signaling by the fasting-induced hormone FGF21." in: Cell metabolism, Vol. 8, Issue 1, pp. 77-83, 2008 (PubMed).