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Details for Product No. ABIN269641

Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody

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Antigen
Synonyms CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, C85791, Cd31, Pecam
Reactivity
»Alternatives Mouse (Murine)
Host
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 8 references available
Catalog no. ABIN269641
Quantity 0.1 mg
Price
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Immunogen Polyoma middle T transformed EC line tEnd.1.
Clone MEC13-3
Cross-Reactivity Mouse (Murine)
Purification Aff - Purified
Alternative Name CD31 / PECAM1
Background CD31 is a 130-140 kD glycoprotein, also known as platelet endothelial cell adhesionmolecule (PECAM-1), EndoCAM, and gpIIa. It is a member of the Ig superfamily,expressed on endothelial cells, platelets, granulocytes, monocytes/macrophages,dendritic cells, and T and B cell subsets, and is critical for cell-to-cell interactions. Theprimary ligands for CD31 have been reported to be CD38 and the vitronectin receptor(á,v â,3 integrin, CD51/CD61). Other reported functions of CD31are neutrophil emigration to sites of inflammation, and angiogenesis. The MEC13.3antibody has been shown to inhibit in vitro and in vivo functions of CD31. Alternate Names: anti-CSPG6 - Chondroitin Sulfate Proteoglycan 6 antibody, anti-BAM - Bamacanantibody, anti-HCAP - Human Chromosome- Associated Polypeptide antibody.
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Suggested working dilutions: flow cytometry / FACS analysis 0.25 ug per 10^6 cells in 100 ul volume.,immunoprecipitation
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Phosphate-buffered solution, pH 7.2. Preservative: 0.09% Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Newman, Berndt, Gorski et al.: "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily." in: Science (New York, N.Y.), Vol. 247, Issue 4947, pp. 1219-22, 1990 (PubMed).

DeLisser, Newman, Albelda: "Molecular and functional aspects of PECAM-1/CD31." in: Immunology today, Vol. 15, Issue 10, pp. 490-5, 1994 (PubMed).

Baldwin, Shen, Yan et al.: "Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development." in: Development (Cambridge, England), Vol. 120, Issue 9, pp. 2539-53, 1994 (PubMed).

Rosenblum, Murata, Nelson et al.: "Anti-CD31 delays platelet adhesion/aggregation at sites of endothelial injury in mouse cerebral arterioles." in: The American journal of pathology, Vol. 145, Issue 1, pp. 33-6, 1994 (PubMed).

Vecchi, Garlanda, Lampugnani et al.: "Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium." in: European journal of cell biology, Vol. 63, Issue 2, pp. 247-54, 1994 (PubMed).

Christofidou-Solomidou, Nakada, Williams et al.: "Neutrophil platelet endothelial cell adhesion molecule-1 participates in neutrophil recruitment at inflammatory sites and is down-regulated after leukocyte extravasation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 10, pp. 4872-8, 1997 (PubMed).

DeLisser, Christofidou-Solomidou, Strieter et al.: "Involvement of endothelial PECAM-1/CD31 in angiogenesis." in: The American journal of pathology, Vol. 151, Issue 3, pp. 671-7, 1997 (PubMed).

Voswinckel, Ziegelhoeffer, Heil et al.: "Circulating vascular progenitor cells do not contribute to compensatory lung growth." in: Circulation research, Vol. 93, Issue 4, pp. 372-9, 2003 (PubMed).

Alternatives for antigen "Platelet/endothelial Cell Adhesion Molecule (PECAM1)", type "Antibodies"
Hosts (317), (136), (85), (4), (3), (1)
Reactivities (387), (179), (70), (43), (30), (23), (12), (11), (3), (2), (1)
Applications (318), (187), (120), (93), (89), (71), (68), (47), (28), (25), (20), (19), (9), (8), (4), (4), (2), (2), (1), (1), (1), (1)
Conjugates (56), (50), (33), (19), (9), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (35), (6), (5), (5), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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