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Details for Product No. ABIN269718

Forkhead Box P3 (FOXP3) antibody

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Antigen
Synonyms sf, JM2, scurfin, AIID, DIETER, IPEX, PIDX, XPID, RGD1562112, foxp3, FOXP3
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN269718
Quantity 25 µL
Price
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Immunogen A synthetic peptide made to the C-terminal region of human FOXP3 (between residues400-431).
Specificity This antibody is specific for human FOXP3. Species Reactivity: Human. This antibody does not appear to detect the mouse FOXP3 protein by westernblot, but does work on mouse tissue for IHC (see data below). Other species have notbeen tested.
Cross-Reactivity Human
Alternative Name FOXP3
Background FOXP3 (a 381 amino acid protein) is a member of the forkhead/winged-helix family oftranscriptional regulators and is highly conserved across mammals. FOXP3 is essentialfor normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positiveregulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent inCD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene and amore specific marker of regulatory T cells than other T cells. Alternate Names: anti-FOXP3 antibody, anti-JM2 antibody, anti-AIID antibody, anti-IPEX antibody,anti-PIDX antibody, anti-XPID antibody, anti-DIETER antibody, anti-SCURFIN antibody,anti-forkhead box P3 antibody, anti-scurfin antibody, anti-JM2 protein antibody,anti-immunodeficiency antibody, anti-polyendocrinopathy antibody, anti-enteropathyantibody, anti-X-linked antibody, anti-immune dysregulation antibody,anti-polyendocrinopathy antibody, anti-enteropathy antibody, anti-X-linked antibody,anti-Official Symbol antibody, anti-FOXP3 antibody.
Gene ID 50943
Research Area Immunology, Adaptive Immunity, Transcription Factors
Application Notes By Western blot, this antibody recognizes bands at ~47.2 kDa representing FOXP3. Ithas also been used on frozen sections at 1:150 from mouse thymus from aninfluenza-infected mouse or thymus from healthy mice (C57BL/6). This antibody hasnot been tested in any other application. Suggested working dilution: *Western blot: 1:1,000-1:5,000(ECL)Immunohistochemistry (frozen): 1:150
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Preservative: Sodium Azide
Preservative Sodium azide
Storage 4 °C
Polanczyk, Carson, Subramanian et al.: "Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 4, pp. 2227-30, 2004 (PubMed).

Ochs, Ziegler, Torgerson: "FOXP3 acts as a rheostat of the immune response." in: Immunological reviews, Vol. 203, pp. 156-64, 2005 (PubMed).

Ochando, Yopp, Yang et al.: "Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 6993-7005, 2005 (PubMed).

Ostroukhova, Qi, Oriss et al.: "Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta." in: The Journal of clinical investigation, Vol. 116, Issue 4, pp. 996-1004, 2006 (PubMed).

Alternatives for antigen "Forkhead Box P3 (FOXP3)", type "Antibodies"
Hosts (146), (62), (43), (16)
Reactivities (187), (148), (62), (16), (16), (15), (12), (8), (1), (1)
Applications (172), (95), (60), (45), (43), (20), (10), (9), (9), (7), (7), (6), (3), (3), (3)
Conjugates (19), (13), (12), (9), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (53), (14), (7), (7), (7), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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