Notch 2 (NOTCH2) antibody

Details for Product No. ABIN269894
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Antigen
Synonyms AGS2, HJCYS, hN2, N2, AI853703
Reactivity
Human
(84), (48), (45), (18), (5), (2), (2), (1), (1)
Host
Rabbit
(78), (9), (4), (4), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(66), (55), (27), (21), (15), (10), (6), (3), (2), (2), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN269894
Quantity 0.2 mL
Price
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Immunogen Synthetic Peptide: C-NAAERTPSHSGHLQaa 2396-2409 (the total protein is 2471 aa).
Isotype IgG
Specificity Species Reactivity: Expected to cross-react with Human (100% identity with immunogen) due to sequencehomology. Not yet tested in other species.
Cross-Reactivity Human
Purification Serum
Alternative Name NOTCH2
Background Synthesized in the endoplasmic reticulum as an inactive form which is proteolyticallycleaved by a furin-like convertase in the trans-Golgi network before it reaches theplasma membrane to yield an active, ligand-accessible form. Cleavage results in aC-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding,it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associatedintermediate fragment called notch extracellular truncation (NEXT). This fragment isthen cleaved by presenilin dependent gamma-secretase to release a notch-derivedpeptide containing the intracellular domain (NICD) from the membraneFunctions as areceptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulatecell-fate determination. Upon ligand activation through the released notch intracellulardomain (NICD) it forms a transcriptional activator complex with RBP-J kappa andactivates genes of the enhancer of split locus. Affects the implementation ofdifferentiation, proliferation and apoptotic programs. Alternate Names: anti-N2 antibody.
Gene ID 4853
Application Notes This antibody has only been tested in ELISA against the peptide immunogen, in which astrong response has been detected. This antibody has not been tested in otherapplications.
Restrictions For Research Use only
Format Liquid
Buffer serum with 0.02% sodium azide
Preservative Sodium azide
Storage 4 °C
General Chen, Oh, Hinman et al.: "Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation." in: Journal of neurochemistry, Vol. 97, Issue 1, pp. 30-43, 2006 (PubMed).

Rutenberg, Fischer, Jia et al.: "Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors." in: Development (Cambridge, England), Vol. 133, Issue 21, pp. 4381-90, 2006 (PubMed).

Hosts (78), (9), (4), (4), (3), (1)
Reactivities (84), (48), (45), (18), (5), (2), (2), (1), (1)
Applications (66), (55), (27), (21), (15), (10), (6), (3), (2), (2), (2), (1), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (9), (8), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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