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LC3 Anti Pack antibody

Details for Product No. ABIN270478, Supplier: Log in to see
Antigen
Reactivity
Human, Mouse (Murine)
Host
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Cross-Reactivity Human, Mouse (Murine)
Background LC3, a mammalian homologue of Apg8, was originally identified asmicrotubule-associated protein 1 light chain 3. It is a component of both the MAP1A andMAP1B microtubule-binding domains and the heavy-chain independent regulation ofLC3 expression might modify MAP1 microtubule-binding activity during development.However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic andLC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is thefirst mammalian protein identified that specifically associates with the autophagosomemembranes.
Restrictions For Research Use only
Format Liquid
Product cited in: Cadwell, Liu, Brown, Miyoshi, Loh, Lennerz, Kishi, Kc, Carrero, Hunt, Stone, Brunt, Xavier, Sleckman, Li, Mizushima, Stappenbeck, Virgin: "A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells." in: Nature, Vol. 456, Issue 7219, pp. 259-63, 2008