LC3 Anti Pack antibody

Details for Product No. ABIN270478
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Antigen
Reactivity
Human, Mouse (Murine)
Host
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN270478
Quantity 2 vials
Price
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Cross-Reactivity Human, Mouse (Murine)
Background LC3, a mammalian homologue of Apg8, was originally identified asmicrotubule-associated protein 1 light chain 3. It is a component of both the MAP1A andMAP1B microtubule-binding domains and the heavy-chain independent regulation ofLC3 expression might modify MAP1 microtubule-binding activity during development.However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic andLC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is thefirst mammalian protein identified that specifically associates with the autophagosomemembranes.
Restrictions For Research Use only
Format Liquid
General Cadwell, Liu, Brown et al.: "A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells." in: Nature, Vol. 456, Issue 7219, pp. 259-63, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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