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LC3 Anti Pack antibody

Details for Product No. ABIN270478
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Antigen
Reactivity
Human, Mouse (Murine)
Host
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Quantity 2 vials
Shipping to United States (Change)
Catalog No. ABIN270478
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Cross-Reactivity Human, Mouse (Murine)
Background LC3, a mammalian homologue of Apg8, was originally identified asmicrotubule-associated protein 1 light chain 3. It is a component of both the MAP1A andMAP1B microtubule-binding domains and the heavy-chain independent regulation ofLC3 expression might modify MAP1 microtubule-binding activity during development.However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic andLC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is thefirst mammalian protein identified that specifically associates with the autophagosomemembranes.
Restrictions For Research Use only
Format Liquid
General Cadwell, Liu, Brown et al.: "A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells." in: Nature, Vol. 456, Issue 7219, pp. 259-63, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN270478
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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