LC3 Anti pack antibody

Antigen: LC3 Anti pack

Clonality: Polyclonal

Host: Please enquire

Reactivity: Human

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)

Catalog no.: ABIN270478

Additional Information

Cross-Reactivity: Human, Mouse (Murine)

Description: LC3, a mammalian homologue of Apg8, was originally identified asmicrotubule-associated protein 1 light chain 3. It is a component of both the MAP1A andMAP1B microtubule-binding domains and the heavy-chain independent regulation ofLC3 expression might modify MAP1 microtubule-binding activity during development.However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic andLC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is thefirst mammalian protein identified that specifically associates with the autophagosomemembranes.

Application Details

Restrictions: For Research Use only

Publications

Cadwell, Liu, Brown et al.: "A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells." in: Nature, Vol. 456, Issue 7219, pp. 259-63, 2008 (PubMed).