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Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) antibody

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Mouse (Murine), Rat (Rattus)
(103), (67), (42), (7), (3), (3), (3), (3), (2), (1)
(144), (11), (8), (7), (1), (1)
(3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(110), (99), (33), (17), (13), (11), (8), (8), (6), (3), (2)
Pubmed 2 references available
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Quantity 0.1 mL
Shipping to United States ( )
Immunogen A synthetic peptide (YFSHLKEYVAS) of human TRPV1 (aa: 531-541) conjugated to KLH has been used as the immunogen.
Specificity Immunohistochemical analysis of rat DRG indicates a superb degree of specificity for this serum.
Cross-Reactivity (Details) Not yet tested in other species.
Purification Whole antisera
Alternative Name TRPV1 / Vanilloid receptor 1 (TRPV1 Antibody Abstract)
Background The cloned VR1 is about 95-kDa protein. Both N- and C- termini of VR1 are intracellular.A hexa-transmembrane domains with an additional intra-membrane loop connecting thefifth and sixth transmembrane has been ascribed to the structure of this molecule. Thestructure and amino acid sequence of VR1 is similar to those of the transient receptorpotential (TRP) family of cation channels. FUNCTION: Receptor-activated non-selectivecalcium permeant cation channel involved in detection of noxious chemical and thermalstimuli. Seems to mediate proton influx and may be involved in intracellular acidosis innociceptive neurons. May be involved in mediation of inflammatory pain andhyperalgesia. Sensitized by a phosphatidylinositol second messenger system activatedby receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation byvanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits atime- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractorystate. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heatand vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can beactivated by endogenous compounds, including 12-hydroperoxytetraenoic acid, andendocannabinoids, like anandamide, and bradykinin. SUBUNIT: Self-associates.Probably homotetramer. May also form a heteromeric channel with TRPV3. Interactswith calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably byforming a trimeric complex. SUBCELLULAR LOCATION: Cell membrane, multi-passmembrane protein. ALTERNATIVE PRODUCTS: 3 named isoforms produced byalternative splicing. TISSUE SPECIFICITY: Predominantly expressed in trigeminal anddorsal root sensory ganglia. Isoform 1 and isoform 3 are also expressed in brain andperipheral blood mononuclear cells. Alternate Names: anti-VR1 antibody, anti-Transient receptor potential cation channel subfamily V member1 antibody, anti-TrpV1 antibody, anti-osm-9-like TRP channel 1 antibody, anti-OTRPC1antibody, anti-Vanilloid receptor 1 antibody, anti-Vanilloid receptor type 1-like antibody. Related Diseases: TRP channels
Gene Symbol: TRPV1
Gene ID 7442
Research Area Receptors, Signaling
Application Notes IHC-P. Use at 1:1000 to 1:2000 dilution. This antibody has not been tested in other applications. The optimal dilution should be determined by the end user.
Recommended dilutions: Immunohistochemistry-Paraffin 1:1000-1:2000, Immunohistochemistry
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Nagy, Suantha, Jancsuo et al.: "The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology." in: European journal of pharmacology, Vol. 500, Issue 1-3, pp. 351-69, 2004 (PubMed).

Tominaga, Caterina, Malmberg et al.: "The cloned capsaicin receptor integrates multiple pain-producing stimuli." in: Neuron, Vol. 21, Issue 3, pp. 531-43, 1998 (PubMed).

Catalog No. ABIN271603

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