GDNF Family Receptor alpha 2 (GFRA2) antibody

Details for Product No. ABIN271609
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Antigen
Synonyms NTNRA, RETL2, TRNR2, GDNFRB, NRTNR-ALPHA, Retl2, NTNRALPHA, DKFZP459C0228, GFRA2, ntnra, retl2, trnr2, gdnfrb, nrtnr-alpha, gfra2
Reactivity
Rat (Rattus)
(48), (31), (31), (13), (13), (12)
Host
Rabbit
(45), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(40), (16), (10), (10), (3), (3), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN271609
Quantity 0.1 mL
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Immunogen A synthetic peptide (PRVEKTPSLPDDLSD) as a part of human GFR alpha-2 protein(aa: 376-390) conjugated to KLH.
Specificity Western blot analysis indicates a high level of specificity to GFR alpha-2 for thisantiserum. Species Reactivity: Reacts with Rat. Localization: Accession Number: GFRA2_HUMAN.
Cross-Reactivity Rat (Rattus)
Alternative Name GFRA2 / GDNFR-beta
Background Members of the glial cell line derived neurotrophic factor (GDNF) family, including GDNFand neurturin (NTN), play key roles in the control of vertebrate neuron survival anddifferentiation. Physiological responses to NTN require the presence of a novelglycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor forNTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have beencloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGFbrelated neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa2 recently.GFRa2 binds NTN and mediates activation of RET receptor tyrosine kinase by bothNTN and GDNF. Thus, NTN, GFRa2, and the Ret PTK form a complex to transduceNTN signal and to mediate NTN function. Alternate Names: anti-GDNF family receptor alpha-2 antibody, anti-GFR-alpha-2 antibody, anti-Neurturinreceptor alpha antibody, anti-NTNR-alpha antibody, anti-NRTNR-alpha antibody,anti-TGF-beta-related neurotrophic factor receptor 2 antibody, anti-GDNF receptor betaantibody, anti-GDNFR-beta antibody, anti-RET ligand 2 antibody. Related Diseases: Neurotrophic Receptors
Gene ID 2675, 25136
Application Notes Suggested working dilutions: immunohistochemistry 1:500 to 1:1000,Western Blot 1:500 to 1:1000
Restrictions For Research Use only
Format Liquid
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Storage 4 °C
General Klein, Sherman, Ho et al.: "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor." in: Nature, Vol. 387, Issue 6634, pp. 717-21, 1997 (PubMed).

Rossi, Luukko, Poteryaev et al.: "Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor." in: Neuron, Vol. 22, Issue 2, pp. 243-52, 1999 (PubMed).

Hosts (45), (2), (1), (1)
Reactivities (48), (31), (31), (13), (13), (12)
Applications (40), (16), (10), (10), (3), (3), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (3), (1), (1), (1), (1)
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