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Details for Product No. ABIN271611

Amyloid beta (A4) Precursor Protein (APP) antibody

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Antigen
Synonyms
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10 ... show more
Reactivity
»Alternatives Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro))
Pubmed 3 references available
Catalog no. ABIN271611
Quantity 0.1 mL
Price
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Immunogen Synthetic peptides (C-ETHLHW HTVAKET, aa: 145-157, C-HAH FQKAKERLEAKHRER, aa: 388-405, C-KKKQYTS IHHGVVE, aa: 724-737) as parts of human APPisoform A conjugated to KLH.
Specificity Specificity for APP was confirmed by IHC. Species Reactivity: Reacts with rat. Localization: Accession Number: APP_HUMAN.
Cross-Reactivity Rat (Rattus)
Alternative Name Amyloid beta A4 protein / APP
Background FUNCTION: Functions as a cell surface receptor and performs physiological functionson the surface of neurons relevant to neurite growth, neuronal adhesion andaxonogenesis. Involved in cell mobility and transcription regulation throughprotein-protein interactions. Can promote transcription activation through binding toAPBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples toapoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o)alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonaltransport of beta-secretase and presenilin 1. May be involved in copperhomeostasis/oxidative stress through copper ion reduction. Can regulate neuriteoutgrowth through binding to components of the extracellular matrix such as heparinand collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelatorswith metal-reducing activity. Bind transient metals such as copper, zinc and iron. Ratand mouse beta-amyloid peptides bind only weakly transient metals and have littlereducing activity due to substitutions of transient metal chelating residues. Beta-APP42may activate mononuclear phagocytes in the brain and elicit inflammatory responses.Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity).FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides,including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via itsC-terminus, to the PID domain of several cytoplasmic proteins, including APBB familymembers, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1,APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, itbinds MAPT via the MT-binding domains. Associates with microtubules in the presenceof ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, withGNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloidassociates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues:kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In thecerebellum, all the isoforms are abundantly expressed in Purkinje cells. Alternate Names: anti-AAA antibody, anti-ABETA antibody, anti-ABPP antibody, anti-AD1 antibody,anti-APPI antibody, anti-CTFgamma antibody, anti-CVAP antibody, anti-PN2 antibody. Related Diseases: Other Neuronal
Research Area Neurology, Alzheimer's Disease
Application Notes Suggested working dilutions: immunohistochemistry 1:500 to 1:3000
Restrictions For Research Use only
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Storage 4 °C
Wilson, Doms, Lee: "Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production." in: Journal of neuroscience research, Vol. 74, Issue 3, pp. 361-9, 2003 (PubMed).

Andreasen, Sjoegren, Blennow: "CSF markers for Alzheimer's disease: total tau, phospho-tau and Abeta42." in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 4, Issue 4, pp. 147-55, 2003 (PubMed).

Guuenette: "Mechanisms of Abeta clearance and catabolism." in: Neuromolecular medicine, Vol. 4, Issue 3, pp. 147-60, 2004 (PubMed).

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts (381), (110), (42), (5)
Reactivities (490), (232), (225), (106), (99), (95), (92), (17), (15), (7), (5), (5), (5), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Applications (375), (206), (130), (98), (90), (37), (36), (14), (14), (11), (7), (7), (4), (2), (2), (1), (1), (1), (1)
Conjugates (14), (11), (10), (9), (9), (9), (9), (9), (9), (9), (9), (1), (1)
Epitopes (64), (49), (30), (30), (19), (13), (13), (10), (9), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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