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Amyloid beta (A4) Precursor Protein (APP) antibody

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Rat (Rattus)
(837), (312), (285), (41), (11), (9), (8), (8), (6), (3), (2), (2), (1), (1), (1), (1)
(594), (225), (52), (3), (2)
(49), (37), (35), (17), (13), (13), (13), (13), (13), (13), (13), (13), (11), (11), (11), (2), (2), (1)
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(581), (324), (232), (162), (147), (76), (60), (38), (29), (25), (16), (10), (9), (9), (6), (3), (2), (2), (2), (2), (1)
Pubmed 3 references available
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Quantity 0.1 mL
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Immunogen A synthetic peptide (HMNVQNGKWESDPSGTKTC, aa: 44-62) as part of mouse APP isoform A conjugated to the immunogenic protein Blue Carrier Protein
Specificity Specificity for APP was confirmed by IHC.
Cross-Reactivity (Details) Reactivity with other species has not yet been tested.
Purification Whole antisera
Alternative Name Amyloid beta A4 protein / APP (APP Antibody Abstract)
Background FUNCTION: Functions as a cell surface receptor and performs physiological functionson the surface of neurons relevant to neurite growth, neuronal adhesion andaxonogenesis. Involved in cell mobility and transcription regulation throughprotein-protein interactions. Can promote transcription activation through binding toAPBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples toapoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o)alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonaltransport of beta-secretase and presenilin 1. May be involved in copperhomeostasis/oxidative stress through copper ion reduction. Can regulate neuriteoutgrowth through binding to components of the extracellular matrix such as heparinand collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelatorswith metal-reducing activity. Bind transient metals such as copper, zinc and iron. Ratand mouse beta-amyloid peptides bind only weakly transient metals and have littlereducing activity due to substitutions of transient metal chelating residues. Beta-APP42may activate mononuclear phagocytes in the brain and elicit inflammatory responses.Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity).FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides,including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via itsC-terminus, to the PID domain of several cytoplasmic proteins, including APBB familymembers, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1,APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, itbinds MAPT via the MT-binding domains. Associates with microtubules in the presenceof ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, withGNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloidassociates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues:kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In thecerebellum, all the isoforms are abundantly expressed in Purkinje cells. Alternate Names: anti-AAA antibody, anti-ABETA antibody, anti-ABPP antibody, anti-AD1 antibody,anti-APPI antibody, anti-CTFgamma antibody, anti-CVAP antibody, anti-PN2 antibody. Related Diseases: Other Neuronal
Gene Symbol: APP
Gene ID 351
Research Area Neurology, Alzheimer's Disease
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Application Notes Immunohistochemistry.Recommended to be used at a dilution of 1:500 to 1:3000. This antiserum has not yet been tested for western blot. The optimal working dilution should be determined by the end user.
Recommended dilutions: Immunohistochemistry-Paraffin 1:500-1:3000, Immunohistochemistry
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Guénette: "Mechanisms of Abeta clearance and catabolism." in: Neuromolecular medicine, Vol. 4, Issue 3, pp. 147-60, 2004 (PubMed).

Andreasen, Sjögren, Blennow: "CSF markers for Alzheimer's disease: total tau, phospho-tau and Abeta42." in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, Vol. 4, Issue 4, pp. 147-55, 2003 (PubMed).

Wilson, Doms, Lee: "Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production." in: Journal of neuroscience research, Vol. 74, Issue 3, pp. 361-9, 2003 (PubMed).

Catalog No. ABIN271612

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