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Description
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The cloned VR1 is about 95-kDa protein. Both N- and C- termini of VR1 are intracellular.A hexa-transmembrane domains with an additional intra-membrane loop connecting thefifth and sixth transmembrane has been ascribed to the structure of this molecule. Thestructure and amino acid sequence of VR1 is similar to those of the transient receptorpotential (TRP) family of cation channels. FUNCTION: Receptor-activated non-selectivecalcium permeant cation channel involved in detection of noxious chemical and thermalstimuli. Seems to mediate proton influx and may be involved in intracellular acidosis innociceptive neurons. May be involved in mediation of inflammatory pain andhyperalgesia. Sensitized by a phosphatidylinositol second messenger system activatedby receptor tyrosine kinases, which involves PKC isozymes and PCL. SUBUNIT:Self-associates. Probably homotetramer. May also form a heteromeric channel withTRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG andNTRK1, probably by forming a trimeric complex. SUBCELLULAR LOCATION: Cellmembrane, multi-pass membrane protein. ALTERNATIVE PRODUCTS: 2 namedisoforms produced by alternative splicing. TISSUE SPECIFICITY: Widely expressed atlow levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneoussensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, theinner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweatgland ducts, and the secretory portion of eccrine sweat glands (at protein level).DOMAIN: The association domain (AD) is necessary for self-association. PTM:Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites,probably including Ser-117 as a major phosphorylation site. Phoshphorylation byCAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated byPKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptordesensitization and phosphorylation by CAMKII recovers activity. MISCELLANEOUS:Responses evoked by low pH and heat, and capsaicin can be antagonized bycapsazepine. SIMILARITY: Belongs to the transient receptor family. TrpV subfamily.SIMILARITY: Contains 3 ANK repeats. Alternate Names: anti-VR1 antibody, anti-Transient receptor potential cation channel subfamily V member1 antibody, anti-TrpV1 antibody, anti-osm-9-like TRP channel 1 antibody, anti-OTRPC1antibody, anti-Vanilloid receptor 1 antibody, anti-Vanilloid receptor type 1-like antibody. Related Diseases: TRP channels
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