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Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2) antibody

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Human, Rat (Rattus)
(68), (23), (15), (1), (1), (1), (1), (1), (1), (1), (1)
(67), (28), (2)
(4), (4), (4), (4), (4), (4), (1)
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(60), (42), (23), (23), (4), (3), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.05 mg
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Immunogen A synthetic peptide (C-KNSASEE DHLPLQVLQSP) as part of rat VRL-1 protein (aa: 744-761) conjugated to KLH
Isotype IgG
Purification Affinity purified
Alternative Name TRPV2 / Vanilloid receptor-like protein 1 (TRPV2 Antibody Abstract)
Background Caterina et al has identified a structurally related receptor, VRL-1, that does not respondto capsaicin, acid or moderate heat. Instead, VRL-1 is activated by high temperatures,with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is mostprominently expressed by a subset of medium- to large-diameter neurons, making it acandidate receptor for transducing high-threshold heat responses in this class of cells.VRL-1 transcripts are not restricted to the sensory nervous system, indicating that thischannel may be activated by stimuli other than heat. VRL-1 is one of the six members ofthe vanilloid-like TRP-channel family which is now known as TRPV family. FUNCTION:Calcium-permeable, non-selective cation channel with an outward rectification. Seemsto be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogeneticneuropeptide/head activator. May transduce physical stimuli in mast cells. Activated bytemperatures higher than 52 degrees Celsius, is not activated by vanilloids and acidicpH. SUBUNIT: Homotetramer (Probable). Interacts with a cAMP-dependent proteinkinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts withRGA. SUBCELLULAR LOCATION: Cell membrane, multi-pass membrane protein.Cytoplasm. Translocates from the cytoplasm to the plasma membrane upon ligandstimulation. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in dorsal rootganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsalcolumns) (at protein level). PTM: N-glycosylated. PTM: Phosphorylated by PKA.SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. SIMILARITY:Contains 3 ANK repeats. Alternate Names: anti-Transient receptor potential cation channel subfamily V member 2 antibody,anti-TrpV2 antibody, anti-osm-9-like TRP channel 2 antibody, anti-OTRPC2 antibody,anti-Vanilloid receptor-like protein 1 antibody, anti-Stretch-activated channel 2B antibody. Related Diseases: TRP channels
Gene Symbol: TRPV2
Gene ID 51393, 29465
Application Notes This antiserum works superbly for immunohistochemistry on free-floating or paraffin embedded sections.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 50 µL of sterile water.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Jahnel, Bender, Münter et al.: "Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression." in: European journal of biochemistry / FEBS, Vol. 270, Issue 21, pp. 4264-71, 2003 (PubMed).

Caterina, Rosen, Tominaga et al.: "A capsaicin-receptor homologue with a high threshold for noxious heat." in: Nature, Vol. 398, Issue 6726, pp. 436-41, 1999 (PubMed).

Catalog No. ABIN271617

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