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Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2) antibody

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Human, Rat (Rattus)
(68), (23), (15), (1), (1), (1), (1), (1), (1), (1), (1)
(67), (28), (2)
(4), (4), (4), (4), (4), (4), (1)
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(60), (42), (23), (23), (4), (3), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 0.1 mL
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Immunogen A synthetic peptide (C-KNSASEE DHLPLQVLQSP) as part of rat VRL-1 protein (aa: 744-761) conjugated to KLH.
Purification Whole antisera
Alternative Name TRPV2 / Vanilloid receptor-like protein 1 (TRPV2 Antibody Abstract)
Background Caterina et al has identified a structurally related receptor, VRL-1, that does not respondto capsaicin, acid or moderate heat. Instead, VRL-1 is activated by high temperatures,with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is mostprominently expressed by a subset of medium- to large-diameter neurons, making it acandidate receptor for transducing high-threshold heat responses in this class of cells.VRL-1 transcripts are not restricted to the sensory nervous system, indicating that thischannel may be activated by stimuli other than heat. VRL-1 is one of the six members ofthe vanilloid-like TRP-channel family which is now known as TRPV family. FUNCTION:Calcium-permeable, non-selective cation channel with an outward rectification. Seemsto be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogeneticneuropeptide/head activator. May transduce physical stimuli in mast cells. Activated bytemperatures higher than 52 degrees Celsius, is not activated by vanilloids and acidicpH. SUBUNIT: Homotetramer (Probable). Interacts with a cAMP-dependent proteinkinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts withRGA. SUBCELLULAR LOCATION: Cell membrane, multi-pass membrane protein.Cytoplasm. Translocates from the cytoplasm to the plasma membrane upon ligandstimulation. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in dorsal rootganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsalcolumns) (at protein level). PTM: N-glycosylated. PTM: Phosphorylated by PKA.SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. SIMILARITY:Contains 3 ANK repeats. Alternate Names: anti-Transient receptor potential cation channel subfamily V member 2 antibody,anti-TrpV2 antibody, anti-osm-9-like TRP channel 2 antibody, anti-OTRPC2 antibody,anti-Vanilloid receptor-like protein 1 antibody, anti-Stretch-activated channel 2B antibody. Related Diseases: TRP channels
Gene Symbol: TRPV2
Gene ID 51393, 29465
Application Notes Recommended dilutions: Immunohistochemistry-Paraffin 1:1000-1:2000, Western Blot 1:1000-1:2000, Immunocytochemistry/Immunofluorescence 1:50-1:200, Immunohistochemistry
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized whole antiserum. Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Caterina, Rosen, Tominaga et al.: "A capsaicin-receptor homologue with a high threshold for noxious heat." in: Nature, Vol. 398, Issue 6726, pp. 436-41, 1999 (PubMed).

Catalog No. ABIN271618

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