Glial Cell Derived Neurotrophic Factor (GDNF) antibody

Details for Product No. ABIN271619
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Antigen
Reactivity
Human
(68), (23), (18), (13), (13), (13), (13), (1)
Host
Rabbit
(56), (6), (4), (3), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(55), (20), (14), (14), (10), (8), (6), (6), (3), (3), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN271619
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Immunogen A synthetic peptide (HSDPARRGEL) as a part of human BDNF protein (aa: 129-138) conjugated to KLH has been used as the immunogen. The BDNF protein sequence is highly conserved amongst primates.
Specificity No cross reativity with NTN has been observed in western blot analysis.
Purification Whole antisera
Alternative Name GDNF
Background GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discoveredas a potent survival factor for midbrain dopaminergic neurons and was then shown torescue these neurons in animal models of Parkinson's disease. GDNF is about 100times more efficient survival factor for spinal motor neurons than the neurotrophins. ,FUNCTION: Neurotrophic factor that enhances survival and morphologicaldifferentiation of dopaminergic neurons and increases their high-affinity dopamineuptake. SUBUNIT: Homodimer, disulfide-linked. SUBCELLULAR LOCATION: Secretedprotein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternativesplicing. , DISEASE: Defects in GDNF may be a cause of Hirschsprung disease(HSCR). In association with mutations of RET gene, defects in GDNF may be involvedin Hirschsprung disease. This genetic disorder of neural crest development ischaracterized by the absence of intramural ganglion cells in the hindgut, often resultingin intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital centralhypoventilation syndrome (CCHS), also known as congenital failure of autonomiccontrol or Ondine curse. CCHS is a rare disorder characterized by abnormal control ofrespiration in the absence of neuromuscular or lung disease, or an identifiable brainstem lesion. A deficiency in autonomic control of respiration results in inadequate ornegligible ventilatory and arousal responses to hypercapnia and hypoxemia.SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily. Alternate Names: anti-Glial cell line-derived neurotrophic factor antibody, anti-Astrocyte-derived trophicfactor 1 antibody, anti-ATF-1 antibody. Related Diseases: Neurotrophic Factors
Gene Symbol: GDNF
Gene ID 2668, 14573, 25453
Research Area Organogenesis, Growth Factors
Application Notes Western blot. Recommended to be used at a dilution of 1:1000 to 1:3000 for Western blot. The optimal working dilution should be determined by the end user. The predicted molecular weight of the GDNF monomer is 11.6 kDa.
Recommended dilutions: ELISA, Western Blot 1:1000 to 1:3000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Lin, Doherty, Lile et al.: "GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons." in: Science (New York, N.Y.), Vol. 260, Issue 5111, pp. 1130-2, 1993 (PubMed).

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