Huntingtin Associated Protein 1 (HAP1) antibody

Details for Product No. ABIN271628
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Antigen
Reactivity
Rat (Rattus)
(38), (30), (29), (12), (12)
Host
Rabbit
(34), (11), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(30), (21), (14), (12), (10), (3), (3), (2)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN271628
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Immunogen Recombinant rat HAP-1
Specificity Specificity for HAP-1 was confirmed by IHC.
Cross-Reactivity (Details) Other species have not yet been tested.
Purification Whole antisera
Alternative Name HAP1
Background Huntington',s disease (HD), a neurodegenerative disorder characterized by loss ofstriatal neurons, is caused by an expansion of a polyglutamine tract in the HD proteinhuntingtin. It is a progressive disorder that generally begins in middle age withabnormalities of movement, cognition, personality and mood. Huntingtin-associatedprotein-1 is highly expressed in brain and shown to mediate the neuropathology of HD.The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin andpericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulatedtyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinasesubstrate suggest a role for this protein in vesicular trafficking or organelle transport.Two transcripts encoding different isoforms have been identified but one is anonsense-mediated decay (NMD) candidate. Alternate Names: anti-HAP 1 antibody, anti-HAP 2 antibody, anti-HAP1 antibody, anti-HAP2 antibody,anti-HAPP antibody, anti-hHAP1 antibody, anti-hHLP1 antibody, anti-HIP 5 antibody,anti-HIP5 antibody, anti-HLP antibody, anti-HLP1 antibody, anti-Neuroan 1 antibody,anti-Neuroan1 antibody. Related Diseases: Other Neuronal
Gene Symbol: HAP1
Gene ID 9001
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Tang, Tu, Chan et al.: "Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1." in: Neuron, Vol. 39, Issue 2, pp. 227-39, 2003 (PubMed).

Zhou, Cao, Wang et al.: "Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity." in: The Journal of cell biology, Vol. 163, Issue 1, pp. 109-18, 2003 (PubMed).

Qin, Wang, Sapp et al.: "Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 1, pp. 269-81, 2004 (PubMed).

Harper, Staber, He et al.: "RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 16, pp. 5820-5, 2005 (PubMed).

Pardo, Colin, Ruegulier et al.: "Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 5, pp. 1635-45, 2006 (PubMed).

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