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Huntingtin Associated Protein 1 (HAP1) antibody
|Synonyms||HLP, HAP2, HIP5, hHLP1|
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro))
|5 references available|
|Quantity||0.1 ml (Variants)|
|Price||Product not available in this region.|
|Immunogen||Recombinant rat HAP-1.|
|Description||Huntington',s disease (HD), a neurodegenerative disorder characterized by loss ofstriatal neurons, is caused by an expansion of a polyglutamine tract in the HD proteinhuntingtin. It is a progressive disorder that generally begins in middle age withabnormalities of movement, cognition, personality and mood. Huntingtin-associatedprotein-1 is highly expressed in brain and shown to mediate the neuropathology of HD.The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin andpericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulatedtyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinasesubstrate suggest a role for this protein in vesicular trafficking or organelle transport.Two transcripts encoding different isoforms have been identified but one is anonsense-mediated decay (NMD) candidate. Alternate Names: anti-HAP 1 antibody, anti-HAP 2 antibody, anti-HAP1 antibody, anti-HAP2 antibody,anti-HAPP antibody, anti-hHAP1 antibody, anti-hHLP1 antibody, anti-HIP 5 antibody,anti-HIP5 antibody, anti-HLP antibody, anti-HLP1 antibody, anti-Neuroan 1 antibody,anti-Neuroan1 antibody. Related Diseases: Other Neuronal|
|Specificity||Specificity for HAP-1 was confirmed by IHC. Species Reactivity: Reacts with rat. Localization: Accession Number: HAP1_RAT.|
|Application Notes||Suggested working dilutions: immunohistochemistry 1:500 to 1:3000|
|Buffer||Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.|
|Storage||Store at 4C short term. Aliquot and store at -20 long term. Avoid freeze-thaw cycles.|
|Restrictions||For Research Use only|
Tang, Tu, Chan et al.: "Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1." in: Neuron, Vol. 39, Issue 2, pp. 227-39, 2003 (PubMed).
Zhou, Cao, Wang et al.: "Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity." in: The Journal of cell biology, Vol. 163, Issue 1, pp. 109-18, 2003 (PubMed).
Qin, Wang, Sapp et al.: "Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 1, pp. 269-81, 2004 (PubMed).
Harper, Staber, He et al.: "RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 16, pp. 5820-5, 2005 (PubMed).
Pardo, Colin, Ruegulier et al.: "Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 5, pp. 1635-45, 2006 (PubMed).
|Hosts||Rabbit (27), Goat (8), Mouse (1)|
|Reactivities||Human (30), Mouse (Murine) (27), Rat (Rattus) (25), Cow (Bovine) (18), Dog (Canine) (18), Horse (Equine) (18), Monkey (18)|
|Applications||ELISA (15), Immunofluorescence (IF) (15), Western Blotting (WB) (14), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (3), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)|
|Epitopes||AA 639-653 (2), C-Term (2), Internal Region (2), Middle Region (1)|