Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) antibody

Details for Product No. ABIN271647
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Antigen
Synonyms Park, Prkn
Reactivity
Guinea Pig
(95), (22), (18), (2), (2), (1)
Host
Rabbit
(77), (13), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), ELISA
(85), (48), (38), (22), (11), (9), (7), (4), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN271647
Quantity 0.1 mL
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Immunogen A synthetic peptide (RILGEE QYNRYQQYGA EEC) as part of human Parkin conjugatedto diphtheria toxoid.
Specificity This antiserum is known to specifically recognise Parkin shown by IHC and WB. Species Reactivity: Reacts with guinea pig and rat. Localization: Accession Number: PRKN2_HUMAN.
Cross-Reactivity Guinea Pig, Rat (Rattus)
Alternative Name PARK2 / Parkin
Background Parkinson',s disease is a common neurodegenerative disease with complexclinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible forthe pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role inthe ubiquitin-mediated proteolytic pathway by removal and/or detoxification ofabnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to bethe mechanism underlying pathogenesis of Parkin. Parkin may protect neurons againstalpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, andkainate-induced excitotoxicity. It may play a role in controlling neurotransmittertrafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin alsoregulates cyclin e during neuronal apoptosis and may represent a tumor suppressorgene. Alternate Names: anti-Ubiquitin E3 ligase PRKN antibody, anti-Parkinson juvenile disease protein 2antibody, anti-Parkinson disease protein 2. GENE NAME: PARK2 antibody, anti-PRKNantibody, biosensis. Related Diseases: Alzheimer's/ Parkinson's
Application Notes Suggested working dilutions: ELISA 1:500 to 1:2000,immunohistochemistry 1:500 to 1:2000,Western Blot 1:500 to 1:2000
Restrictions For Research Use only
Format Liquid
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Storage 4 °C
General Kitada, Asakawa, Hattori et al.: "Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism." in: Nature, Vol. 392, Issue 6676, pp. 605-8, 1998 (PubMed).

Hosts (77), (13), (12)
Reactivities (95), (22), (18), (2), (2), (1)
Applications (85), (48), (38), (22), (11), (9), (7), (4), (1), (1)
Conjugates (1)
Epitopes (13), (11), (8), (8), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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