Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) antibody

Details for Product No. ABIN271648
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Antigen
Reactivity
Human
(110), (23), (19), (3), (3), (1), (1)
Host
Rabbit
(85), (20), (13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(100), (61), (41), (24), (10), (10), (9), (6), (6), (2), (1), (1)
Pubmed 6 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN271648
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Immunogen A synthetic peptide (NSLIKELHHFRILGEE Q) as part of human Parkin conjugated to KLH
Purification Whole antisera
Alternative Name PARK2 / Parkin
Background Parkinson',s disease is a common neurodegenerative disease with complexclinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible forthe pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role inthe ubiquitin-mediated proteolytic pathway by removal and/or detoxification ofabnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to bethe mechanism underlying pathogenesis of Parkin. Parkin may protect neurons againstalpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, andkainate-induced excitotoxicity. It may play a role in controlling neurotransmittertrafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin alsoregulates cyclin e during neuronal apoptosis and may represent a tumor suppressorgene. Alternate Names: anti-Ubiquitin E3 ligase PRKN antibody, anti-Parkinson juvenile disease protein 2antibody, anti-Parkinson disease protein 2. GENE NAME: PARK2 antibody, anti-PRKNantibody, biosensis. Related Diseases: Alzheimer's/ Parkinson's
Gene Symbol: PARK2
Gene ID 5071, 56816
Application Notes For IHC: Nice staining is achieved in neuronal and cytoplasmic granules sections treated with citrate buffer for antigen retrieval. Few inclusions are stained but these were not positively identified as Lewy bodies.
Recommended dilutions: Immunohistochemistry 1:1000, Immunohistochemistry-Paraffin 1:1000, Western Blot 1:2000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Buffer Lyophilized whole serum.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Kitada, Asakawa, Hattori et al.: "Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism." in: Nature, Vol. 392, Issue 6676, pp. 605-8, 1998 (PubMed).

West, Kapatos, OFarrell et al.: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).

Wang, Denison, Lai et al.: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004 (PubMed).

Yao, Gu, Nakamura et al.: "Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10810-4, 2004 (PubMed).

Pigullo, De Luca, Barone et al.: "Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor." in: Parkinsonism & related disorders, Vol. 10, Issue 6, pp. 357-62, 2004 (PubMed).

Kumru, Santamaria, Tolosa et al.: "Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations." in: Annals of neurology, Vol. 56, Issue 4, pp. 599-603, 2004 (PubMed).

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