SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) antibody

Details for Product No. ABIN271649
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Antigen
Synonyms
UBL1, pigSUMO1, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, SENTRIN, SMTP3, SUMO-1, Smt3C, Ubl1, CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SUMO, Smt3, Sumo, anon-EST:Posey240, d ... show more
UBL1, pigSUMO1, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, SENTRIN, SMTP3, SUMO-1, Smt3C, Ubl1, CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1, ATSUMO1, F10M23.180, F10M23_180, SMALL UBIQUITIN-LIKE MODIFIER 1, SUM1, SUMO 1, small ubiquitin-like modifier 1, zgc:65934, zgc:85634, hm:zeh0670, wu:fb74c02, wu:fd12c02, SUMO1, sumo-1, sumo1 show less
Reactivity
Human
(121), (69), (64), (24), (23), (12), (11), (2), (1), (1), (1), (1)
Host
Rabbit
(112), (16), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(100), (44), (32), (31), (29), (29), (13), (8), (4), (3), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN271649
Quantity 0.1 mL
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Immunogen A synthetic peptide (AKPST EDLGDKKEGE Y) as part of human SUMO-1 peptide (aa:6-21) conjugated to diphtheria toxoid. This antigen shares 100% identity with SUMO-1of rat.
Specificity This antiserum recognises human SUMO-1 and not ubiquitin. Species Reactivity: Reacts with rat and human. Localization: Accession Number: SUMO1_HUMAN.
Cross-Reactivity Human, Rat (Rattus)
Alternative Name SUMO1
Background FUNCTION: Ubiquitin-like protein which binds to a wide range of target proteins. Doesnot seem to be involved in protein degradation and may function as an antagonist ofubiquitin in the degradation process. Plays a role in a number of cellular processes suchas nuclear transport, DNA replication and repair, mitosis and signal transduction.Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2.SUBUNIT: Covalently attached to a number of proteins such as PML, RANGAP1,HIPK2, SP100, p53, p73alpha, MDM2, JUN and DNMT3B. Also interacts with HIF1A,HIPK2, HIPK3, CHD3, PIAS1, EXOSC9, TDG, RAD51 and RAD52. SUBCELLULARLOCATION: Nucleus, nuclear membrane. Nucleus, nucleoplasm, nuclear speckle.Cytoplasm. SIMILARITY: Belongs to the ubiquitin family. SMT3 subfamily. SIMILARITY:Contains 1 ubiquitin-like domain. Alternate Names: anti-Small ubiquitin-related modifier 1 antibody, anti-Ubiquitin-like protein SMT3Cantibody, anti-SMT3 homolog 3 antibody, anti-Ubiquitin-homology domain protein PIC1antibody, anti-Ubiquitin-like protein UBL1 antibody, anti-GAP-modifying protein 1antibody, anti-GMP1 antibody, anti-Sentrin. GENE NAME: SUMO1 antibody,anti-SMT3C antibody, anti-SMT3H3 antibody, anti-UBL1 antibody, biosensis. Related Diseases: Alzheimer's/ Parkinson's
Research Area Signaling, Proteases, DNA/RNA
Application Notes Suggested working dilutions: immunohistochemistry 1:1000 to 1:2000,Western Blot 1:2000 to 1:4000
Restrictions For Research Use only
Format Liquid
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Storage 4 °C
General Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, 2003 (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, 2003 (PubMed).

Pountney, Huang, Burns et al.: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, 2003 (PubMed).

Ling, Sankpal, Robertson et al.: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, 2004 (PubMed).

Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, 2004 (PubMed).

Hosts (112), (16), (2), (1)
Reactivities (121), (69), (64), (24), (23), (12), (11), (2), (1), (1), (1), (1)
Applications (100), (44), (32), (31), (29), (29), (13), (8), (4), (3), (1), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (23), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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