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TRKB antibody (Neurotrophic Tyrosine Kinase, Receptor, Type 2)

Details for Product anti-NTRK2 Antibody No. ABIN271654, Supplier: Login to see New
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Human, Rat (Rattus)
(244), (149), (145), (9), (6), (4), (4), (4), (2), (1)
(238), (22), (13), (5), (3)
This TRKB antibody is un-conjugated
(5), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(199), (104), (92), (41), (30), (24), (10), (10), (5), (2), (2), (2), (1), (1)
Pubmed 6 references available
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Quantity 0.1 mL
Shipping to United States ( )
Immunogen A synthetic peptide as part of rat TrkB (aa: 23-36) conjugated to KLH. AFPRLEPNSIDPENC
Specificity Sequence was chosen to avoid cross reactivity with trkA and trkC.
Cross-Reactivity (Details) This antiserum recognises human,rat,TrkB. Cross reactivity with other species has not yet been tested.
Purification Whole antisera
Alternative Name TrkB (NTRK2 Antibody Abstract)
Background FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 andneurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/ormaintenance of the nervous system. This is a tyrosine-protein kinase receptor. Knownsubstrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosinephosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity)and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1.SUBCELLULAR LOCATION: Membrane, single-pass type I membrane protein.ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing.Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms aredifferentially expressed in various cell types. Isoform T2 is primarily expressed inneurons. PTM: Ligand-mediated auto-phosphorylation. SIMILARITY: Belongs to the Tyrprotein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 2 Ig-likeC2-type (immunoglobulin-like) domains. SIMILARITY: Contains 2 LRR (leucine-rich)repeats. SIMILARITY: Contains 1 protein kinase domain. Alternate Names: anti-BDNF/NT-3 growth factors receptor antibody, anti-Neurotrophic tyrosine kinasereceptor type 2 antibody, anti-TrkB tyrosine kinase antibody,anti-GP145-TrkB/GP95-TrkB antibody, anti-Trk-B. GENE NAME: Ntrk2 antibody,anti-Trkb antibody. Related Diseases: Neurotrophic Receptors
Gene Symbol: NTRK2
Gene ID 4915, 25054
Research Area Cancer
Pathways RTK Signaling, Neurotrophin Signaling Pathway
Application Notes Immunohistochemistry-P. The sequence of the immunogen and the conjugate are identical to the one used by Yan et al (see the Refs) and the antiserum appears to have similar characteristics.
Recommended dilutions: Immunohistochemistry-Paraffin 1:1000 - 1:3000, Immunohistochemistry
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Stoilov, Castren, Stamm: "Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism." in: Biochemical and biophysical research communications, Vol. 290, Issue 3, pp. 1054-65, 2002 (PubMed).

Yan, Radeke, Matheson et al.: "Immunocytochemical localization of TrkB in the central nervous system of the adult rat." in: The Journal of comparative neurology, Vol. 378, Issue 1, pp. 135-57, 1997 (PubMed).

Allen, Dawbarn, Eckford et al.: "Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain." in: Neuroscience, Vol. 60, Issue 3, pp. 825-34, 1994 (PubMed).

Nakagawara, Liu, Ikegaki et al.: "Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)." in: Genomics, Vol. 25, Issue 2, pp. 538-46, 1995 (PubMed).

Haniu, Talvenheimo, Le et al.: "Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding." in: Archives of biochemistry and biophysics, Vol. 322, Issue 1, pp. 256-64, 1995 (PubMed).

Catalog No. ABIN271654

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