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Details for Product No. ABIN271658

Superoxide Dismutase 1, Soluble (SOD1) antibody

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Antigen
Synonyms
ALS, ALS1, IPOA, SOD, hSod1, homodimer, CG11793, Cu, Cu-Zn SOD, Cu/Zn SOD, Cu/Zn sod, Cu/Zn superoxide dismutase, Cu/ZnSOD, CuSOD, CuZn SOD, CuZn-SOD, CuZn-SOD1, CuZnSOD, Cu[2+]/Zn[2+]SOD, Dmel\\CG117 ... show more
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN271658
Quantity 0.1 mL
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Immunogen A synthetic peptide (ASGEPVV LSGQIT) as part of mouse superoxide dismutase(SOD1) protein (aa: 24-36) conjugated to diphtheria toxoid.
Specificity Specificity was confirmed by western blot detecting mouse superoxide dismutase(SOD1). Species Reactivity: This antiserum is known to react with mouse and rat superoxide dismutase (SOD1)protein. Localization: Accession Number: SODC_MOUSE.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Alternative Name Superoxide Dismutase 1 (SOD1)
Background FUNCTION: Destroys radicals which are normally produced within the cells and whichare toxic to biological systems. CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 +H2O2. COFACTOR: Binds 1 copper ion per subunit. COFACTOR: Binds 1 zinc ion persubunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE:Defects in SOD1 are the cause of familial amyotrophic lateral sclerosis (FALS), alsocalled amyotrophic lateral sclerosis 1 (ALS1 or ALS). ALS is a degenerative disorder ofmotorneurons in the cortex, brainstem and spinal cord. ALS is characterized bymuscular weakness and atrophy beginning in the hands and spreading to the forearmsand legs. Muscle fasciculations are commonly visible. Sensory abnormalities areabsent. Death usually occurs within 2 to 5 years. ALS is sometimes referred to as LouGehrig disease after the famous American baseball player who was diagnosed with thedisorder. FALS, the familial form of ALS, accounts for about 10% of the cases and istransmitted in an autosomal dominant manner. The mean age at onset of FALS is 45years. MISCELLANEOUS: Zinc binding promotes dimerization. SIMILARITY: Belongs tothe Cu-Zn superoxide dismutase family. Alternate Names: anti-ALS antibody, anti-ALS1 antibody, anti-IPOA antibody, anti-SOD antibody,anti-homodimer antibody, biosensis. Related Diseases: Antioxidant Enzymes
Research Area Inflammation, Enzymes, Metabolism
Application Notes WB. A dilution of 1:500 to 1:1000 is recommended for this application. The optimaldilution should be determined by the end user.
Restrictions For Research Use only
Buffer Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Preservative: No Preservative.
Levanon, Lieman-Hurwitz, Dafni et al.: "Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase." in: The EMBO journal, Vol. 4, Issue 1, pp. 77-84, 1985 (PubMed).

Hallewell, Masiarz, Najarian et al.: "Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library." in: Nucleic acids research, Vol. 13, Issue 6, pp. 2017-34, 1985 (PubMed).

Sherman, Dafni, Lieman-Hurwitz et al.: "Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 18, pp. 5465-9, 1983 (PubMed).

Jabusch, Farb, Kerschensteiner et al.: "Some sulfhydryl properties and primary structure of human erythrocyte superoxide dismutase." in: Biochemistry, Vol. 19, Issue 11, pp. 2310-6, 1980 (PubMed).

Alternatives for antigen "Superoxide Dismutase 1, Soluble (SOD1)", type "Antibodies"
Hosts (161), (69), (11), (10), (6), (1)
Reactivities (180), (82), (80), (64), (13), (11), (11), (8), (7), (7), (7), (6), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Applications (214), (149), (62), (52), (51), (28), (24), (17), (13), (11), (10), (5), (4), (3), (2), (2), (2), (2), (1)
Conjugates (14), (8), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (11), (7), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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