Myeloperoxidase (MPO) antibody

Details for Product No. ABIN271660
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Antigen
Reactivity
Human
(302), (50), (47), (24), (24), (12), (1), (1)
Host
Rabbit
(175), (147), (2), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(26), (17), (8), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(173), (167), (84), (51), (41), (29), (29), (25), (20), (19), (4), (4), (4), (2), (1), (1)
Pubmed 6 references available
Quantity 0.25 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN271660
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Immunogen Myeloperoxidase isolated from human polymorphonuclear leucocytes
Isotype IgG
Specificity This antiserum reacts with human myeloperoxidase.
Purification Whole antisera
Alternative Name Myeloperoxidase
Background FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It isresponsible for microbicidal activity against a wide range of organisms. In the stimulatedPMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid inphysiologic situations, and other toxic intermediates that greatly enhance PMNmicrobicidal activity. MPO is an important marker for myeloid cells, from thepromyelocyte stage and to the mature forms.CATALYTIC ACTIVITY: Donor + H2O2 = oxidized donor + 2 H2O.CATALYTIC ACTIVITY: Cl- + H2O2 = HOCl + 2 H2O.COFACTOR: Binds 1 calcium ion per heterodimer.COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.SUBUNIT: Tetramer of two light chains and two heavy chains.SUBCELLULAR LOCATION: Lysosome.ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing.DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD). MPD isan autosomal recessive defect that results in disseminated candidiasis.SIMILARITY: Belongs to the peroxidase family. XPO subfamily. Related Diseases: MPO
Gene Symbol: MPO
Gene ID 4353
Research Area Cancer, Innate Immunity, Enzymes, Metabolism, Immunology
Application Notes IHC, WB. This antiserum works superbly for staining of paraffin-embedded tissue sections fixed in formalin, frozen sections and cell cytospins. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add diH20 to desired concentration.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Pinkus, Pinkus: "Myeloperoxidase: a specific marker for myeloid cells in paraffin sections." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 4, Issue 6, pp. 733-41, 1992 (PubMed).

Kimura, Ikeda-Saito: "Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family." in: Proteins, Vol. 3, Issue 2, pp. 113-20, 1988 (PubMed).

Weil, Rosner, Reid et al.: "Translocation and rearrangement of myeloperoxidase gene in acute promyelocytic leukemia." in: Science (New York, N.Y.), Vol. 240, Issue 4853, pp. 790-2, 1988 (PubMed).

Lanza: "Clinical manifestation of myeloperoxidase deficiency." in: Journal of molecular medicine (Berlin, Germany), Vol. 76, Issue 10, pp. 676-81, 1998 (PubMed).

Arber, Snyder, Fine et al.: "Myeloperoxidase immunoreactivity in adult acute lymphoblastic leukemia." in: American journal of clinical pathology, Vol. 116, Issue 1, pp. 25-33, 2001 (PubMed).

Kim, Kimura, Ochiai et al.: "Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster." in: The Japanese journal of veterinary research, Vol. 51, Issue 2, pp. 113-20, 2003 (PubMed).

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