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Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C) (N-Term) antibody

Details for Product No. ABIN271665
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Antigen
Synonyms ATG8J, LC3C, MAP1LC3C, MGC154878
Epitope
N-Term
(7), (6), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(35), (13), (12), (12), (12), (1), (1)
Host
Rabbit
(30), (3), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
(21), (13), (10), (10), (4), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
Catalog No. ABIN271665
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  • +1 404 474 4654
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Immunogen A synthetic peptide (CQEEVAGIRAKF) corresponding to the N-terminal of human MAP1LC3 C (MAP1LC3C, APG8c) conjugated to Blue Carrier Protein has been used as the immunogen. The peptide is homologous with the corresponding sequence deriven from MAP1LC3 C (MAP1LC3C, APG8c) protein in Macaca mulatta (monkey) and Canis familiaris (dog).
Specificity IHC and WB confirmed the specificity for MAP1LC3 C (MAP1LC3C, APG8c). This should recognise MAP1LC3 C only and not the other forms MAP1LC3A and MAP1LC3B.
Cross-Reactivity (Details) other species have not yet been tested.
Purification Whole antisera
Alternative Name MAP1LC3C
Background FUNCTION: Probably involved in formation of autophagosomal vacuoles(autophagosomes). SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associatewith MAP1A and MAP1B proteins. SUBCELLULAR LOCATION: LC3-I: Cytoplasm.LC3-II: Intracytoplasmic membrane, lipid-anchor. LC3-II binds to the autophagicmembranes. TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary. PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I.This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipidto form the membrane-bound form, LC3-II. SIMILARITY: Belongs to the MAP1 LC3family. Alternate Names: anti-Microtubule-associated proteins 1A/1B light chain 3C antibody,anti-Microtubule-associated protein 1 light chain 3 gamma antibody,anti-MAP1A/MAP1B LC3 C antibody, anti-MAP1A/1B light chain 3 C antibody,anti-MAP1 light chain 3-like protein 3 antibody, anti-Autophagy-related protein LC3 Cantibody, anti-Autophagy-related ubiquitin-like modifier LC3 C antibody, anti-APG8c,biosensis. GENE NAME: MAP1LC3C antibody. Related Diseases: Autophagy
Gene Symbol: MAP1LC3C
Gene ID 440738
Application Notes IHC-P, immunofluorescence, WB. A dilution of 1:100 to 1:1000 dilution is recommended for these applications. The optimal working dilution should be determined by the end user.
Recommended dilutions: Immunocytochemistry/Immunofluorescence 1:100-1:1000, Immunohistochemistry 1:100-1:1000, Western Blot 1:100-1:1000
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water.
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
General Tanida, Ueno, Kominami: "LC3 conjugation system in mammalian autophagy." in: The international journal of biochemistry & cell biology, Vol. 36, Issue 12, pp. 2503-18, 2004 (PubMed).

Levine: "Eating oneself and uninvited guests: autophagy-related pathways in cellular defense." in: Cell, Vol. 120, Issue 2, pp. 159-62, 2005 (PubMed).

Lum, DeBerardinis, Thompson: "Autophagy in metazoans: cell survival in the land of plenty." in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 439-48, 2005 (PubMed).

Baehrecke: "Autophagy: dual roles in life and death?" in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 505-10, 2005 (PubMed).

Greenberg: "Degrade or die: a dual function for autophagy in the plant immune response." in: Developmental cell, Vol. 8, Issue 6, pp. 799-801, 2005 (PubMed).

Hosts (30), (3), (1), (1)
Reactivities (35), (13), (12), (12), (12), (1), (1)
Applications (21), (13), (10), (10), (4), (3), (2), (1)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (3), (2), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN271665
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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